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Volume 14, Number 7—July 2008


AIDS Patient Death Caused by Novel Cryptococcus neoformans × C. gattii Hybrid

Marjan Bovers*12, Ferry Hagen*†1Comments to Author , Eiko E. Kuramae*, Hans L. Hoogveld‡, Françoise Dromer§, Guy St-Germain¶, and Teun Boekhout*†
Author affiliations: *Centraalbureau voor Schimmelcultures–Fungal Biodiversity Centre, Utrecht, the Netherlands; †University Medical Centre Utrecht, Utrecht; ‡Netherlands Institute of Ecology, Nieuwersluis, the Netherlands; §Institut Pasteur, Paris, France; ¶Laboratoire Santé Publique Quebec, Sainte-Anne-de-Bellevue, Quebec, Canada;

Main Article


Cryptococcus spp. strains used in this study*

Strain† Mating type‡/serotype AFLP/M13 genotype§ Source Country
CBS9172 aA AFLP1/VNI Soil sample from garden of patient with neighboring bird colonies Italy
CBS8710 (H99) αA AFLP1/VNI Patient with Hodgkin disease United States
CBS1622 αB AFLP4/VGI Tumor France
CBS6992 αB AFLP4/VGI Human Unknown
E566 aB AFLP4/VGI Eucalyptus camaldulensis Australia
CBS10510 (WM276) αB AFLP4/VGI Debris of E. tereticornis Australia
CBS10488 (AMC770616) αBaD AFLP8/NA Human CSF The Netherlands
CBS10489 (AMC2010404) αBaD AFLP8/NA Human CSF The Netherlands
CBS10490 (AMC2011225) αBaD AFLP8/NA Human CSF The Netherlands
CBS10496 (LSPQ#308) αA–B AFLP9/NA Blood of an HIV-positive patient Canada

*AFLP, amplified fragment length polymorphism; CBS, Fungal Biodiversity Centre; AMC, Netherlands Reference Laboratory for Bacterial Meningitis, Academic Medical Center, Amsterdam, the Netherlands; NA, not applicable; CSF, cerebrospinal fluid.
†Origin and genetic composition of the strains are indicated.
‡ –, mating type unknown.
§AFLP fingerprint genotype (7), followed by corresponding M13 PCR fingerprint genotype (8).

Main Article

1These authors contributed equally to this article.

2Current affiliation: Netherlands Commission on Genetic Modification, Bilthoven, the Netherlands.