Volume 14, Number 8—August 2008
Research
Genetic and Serologic Properties of Zika Virus Associated with an Epidemic, Yap State, Micronesia, 2007
Robert S. Lanciotti*
, Olga L. Kosoy*, Janeen J. Laven*, Jason O. Velez*, Amy J. Lambert*, Alison J. Johnson*, Stephanie M. Stanfield*, and Mark R. Duffy*
, Olga L. Kosoy*, Janeen J. Laven*, Jason O. Velez*, Amy J. Lambert*, Alison J. Johnson*, Stephanie M. Stanfield*, and Mark R. Duffy*
Table 1
IgG and IgM testing with heterologous flaviviruses of patients infected with ZIKV, Yap State, Micronesia, 2007*
| Patient | Days after onset | IgG | IgM | ||||||
|---|---|---|---|---|---|---|---|---|---|
| ZIKV | ZIKV | DENV | YFV | JEV | MVEV | WNV | |||
| Primary flavivirus ZIKV | |||||||||
| 822a | 5 | 1.5 | 23.2 | 1.3 | 1.4 | 1.7 | 1.1 | – | |
| 822b | 10 | 1.2 | 39.5 | 1.2 | 1.0 | 2.4 | 1.2 | – | |
| 822c | 24 | 3.3 | 13.1 | 2.7 | 0.63 | 1.8 | 1.3 | – | |
| 830a | 2 | 1.1 | 1.3 | 4.4 | 0.48 | 4.4 | 2.9 | – | |
| 830b | 21 | 1.8 | 16.3 | 1.9 | 0.63 | 1.3 | 1.6 | – | |
| 849a | 3 | 1.5 | 4.5 | 0.92 | 0.95 | 1.2 | 0.66 | – | |
| 849b | 18 | 3.0 | 18.2 | 2.2 | 1.0 | 2.7 | 1.5 | – | |
| 862a | 6 | 1.9 | 25.4 | 1.7 | 1.1 | 1.8 | 1.0 | – | |
| 862b | 20 | 2.6 | 15.4 | 2 | 1.1 | 2.3 | 1.1 | Eq | |
| Secondary flavivirus ZIKV (probable) | |||||||||
| 817a | 1 | 5.9 | 1.4 | 1.7 | 0.8 | 1.7 | 0.7 | – | |
| 817b | 19 | 5.7 | 8.1 | 5.1 | 2.1 | 1.7 | 1.0 | – | |
| 833a | 1 | 3.4 | 1.7 | 3.7 | 1.0 | 2.8 | 1.3 | – | |
| 833b | 19 | 8.2 | 3.1 | 2.3 | 0.9 | 2.5 | 1.3 | – | |
| 844a | 2 | 3.8 | 3.8 | 6.8 | 2.0 | 21.5 | 0.7 | – | |
| 844b | 16 | 8.5 | 12.7 | 14.9 | 7.0 | 42.9 | 1.6 | – | |
| 955a | 1 | 5.0 | 1.8 | 3.7 | 1.0 | 3.4 | 2.4 | Eq | |
| 955b | 14 | 26.6 | 10.9 | 3.4 | 0.8 | 1.7 | 4.0 | Eq | |
| 968a | 1 | 4.0 | 1.7 | 1.3 | 0.6 | 1.2 | 1.2 | – | |
| 968b | 3 | 12.3 | 20.4 | 2.9 | 0.8 | 0.9 | 2.0 | – | |
| 839a | 3 | 1 | 0.92 | 3.4 | 0.7 | 2.7 | 2.1 | – | |
| 839b | 20 | 4.9 | 17.2 | 2.2 | 2.1 | 1.9 | 1.8 | – | |
| 847a | 5 | 0.9 | 0.94 | 4.1 | 4.1 | 2.3 | 1.3 | – | |
| 847b | 8 | 14.1 | 21.5 | 1.4 | 3.3 | 1.1 | 2.6 | – | |
*Ig, immunoglobulin; ZIKV, Zika virus; DENV, dengue virus type 1–4 mixture; YFV, yellow fever virus; JEV, Japanese encephalitis virus; MVEV, Murray Valley encephalitis virus; WNV, West Nile virus; –, negative. Eq, result in equivocal range of the assay. IgG and IgM testing was conducted by ELISA except for WNV, which was tested by microsphere assay; ELISA values are patient optical densities divided by negative control optical densities; <2, negative; 2–3 equivocal; >3 positive.
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