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Volume 14, Number 9—September 2008
Letter

Indigenous Dengue Fever, Buenos Aires, Argentina

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To the Editor: For 2 decades dengue has increased in the Americas, with epidemic peaks every 3 to 5 years (1). The disease has reemerged in 3 South American countries bordering Argentina, namely, Bolivia, Brazil, and Paraguay.

Argentina had remained free from dengue for >80 years before the disease was reintroduced in 1998 (2) as a consequence of insufficient mosquito control and importation of cases from disease-epidemic areas. Since then, indigenous dengue circulation has only been reported in the northern provinces of the country, which are close to endemoepidemic countries. However, the principal dengue vector, the Aedes aegypti mosquito,, has spread southward to latitude 35°S near Buenos Aires (3).

We describe what might be the southernmost indigenous case of dengue fever documented in South America; this case occurred in 2007, an epidemic peak year for the disease on this continent (1). The patient was a pneumonologist who worked part-time at Muñiz Hospital, a referral infectious diseases treatment center in the Buenos Aires Federal District. She also provided healthcare at an outpatient clinic in Lanus, her town of residence, a suburb 6 km south of the Federal District. Febrile illness started suddenly in February 2007, midsummer season in Argentina. On day 5 of illness, fever was replaced by a short-lived rash and itching followed by asthenia and nausea that persisted for 2 days. The patient had not traveled or been accidentally exposed to patients’ blood during the previous weeks. She had never been vaccinated against yellow fever. Dengue fever was only suspected retrospectively.

Serologic results provided supportive evidence of a recent dengue infection i.e., presence of immunoglobulin M, as determined by antibody-capture enzyme immunoassay, and immunoglobulin G seroconversion by 90% plaque reduction neutralization test on Vero cells (4). As shown in the Table, dengue virus serotype 3 was identified, and antibody results were negative for 3 other flaviviruses. Thus, this case fulfils Pan American Health Organization criteria for the diagnosis of dengue fever (5). Household contacts were seronegative.

For several years, conditions have been set for dengue virus circulation in Buenos Aires’ urban and suburban areas because of the abundance of mosquitoes and disease in persons recently returning from neighboring countries. Risk for vector transmission is highest in the peripheral quarters of the city and towards late summer (6). Besides, Buenos Aires, like other Latin American metropolitan areas, is undergoing demographic changes that convey further risk for mosquito-borne disease transmission, namely, accelerated population growth mainly caused by informal settlements, deficient public health infrastructure and basic services, unregulated immigration from neighboring countries, and increased international mobility especially in or from neighboring countries (1).

Only imported dengue cases have been previously documented in Buenos Aires (2). According to official information, all 158 cases confirmed by antibody conversion in Buenos Aires Federal District and Province during 2007 were also imported (7). Of these, 50 occurred in the southern suburban district where our patient lives and works. In the summer of 2007, dengue infection was mainly introduced into the area by Paraguayan natives living in Buenos Aires who had recently visited their homeland. Dengue 3 serotype conversion was demonstrated in most of the cases investigated by plaque reduction neutralization assay, except for a few cases imported from Brazil, in which dengue 1 serotype was detected.

Most of the patients whose cases were diagnosed in Buenos Aires, including 5 who required hospitalization, were referred to Muñiz Hospital. Built a century ago, Muñiz Hospital comprises a number of independent pavilions surrounded by a spacious garden, where mosquitoes thrive, especially in summer. Thus, vector-borne infection in this case might have occurred either in Muñiz Hospital, in the Federal District, or in the southern city suburb, where the patient lives and works.

Until recently, dengue had not been suspected in patients with a fever living in the Buenos Aires area in the absence of a recent history of travel to an endemoepidemic area. Confirmation of our case was evidence of local circulation of dengue virus. Thereafter, serum testing became recommended in Buenos Aires for acute febrile illness, among other dengue surveillance interventions in the area. More recently, epidemiologic surveillance of febrile illness has been strengthened countrywide upon the recent reporting of yellow fever cases in Argentina (8).

No circulation of dengue virus was reported in Buenos Aires during the first 10 epidemiologic weeks of 2008. However, vector control measures should be strengthened to minimize the risk of infective persons triggering an epidemic of dengue or other flavivirus disease.

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Marcela Natiello, Viviana RitaccoComments to Author , María Alejandra Morales, Bettina Deodato, Marisa Picollo, Edith Dinerstein, and Delia Enria

Author affiliations: Hospital “F. J. Muñiz,” Buenos Aires, Argentina (M. Natiello, B. Deodato, M. Picollo); Consejo Nacional de Investigaciones Científicas y Técnicas CONICET, Buenos Aires (V. Ritacco); Hospital Interzonal de Agudos “Evita,” Lanús, Argentina (E. Dinerstein); Instituto Nacional de Enfermedades Virales Humanas "Dr. Julio I. Maiztegui,”, Pergamino, Argentina (M.A. Morales, D. Enria);

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References

  1. Pan American Health Organization. Dengue in the Americas: 2007 summary. EID updates: emerging and reemerging infectious diseases, region of the Americas. 2007 [cited 2008 Mar 13]. Available from http://www.paho.org/english/ad/dpc/cd/eid-eer-2007-09-26.htm#sit
  2. Seijo  A, Cernigoi  B, Deodato  B. Dengue imported from Paraguay to Buenos Aires. Clinical and epidemiological report of 38 cases [in Spanish]. Medicina (B Aires). 2001;61:13741.PubMed
  3. Avilés  G, Paz  MV, Rangeon  G, Ranaivoarisoa  MY, Verzeri  N, Roginski  S, Laboratory surveillance of dengue in Argentina, 1995–2001. Emerg Infect Dis. 2003;9:73842.PubMed
  4. Enria  D, Morales  MA, Fabbri  C. Dengue. In: Cecchini E, González Ayala E, editors. Infectología y Enfermedades Infecciosas. Buenos Aires: Ediciones Journal; 2007. p. 638–42.
  5. Pan American Health Organization. Dengue and dengue hemorrhagic fever in the Americas: guidelines for prevention and control. PAHO scientific publication no. 548. Washington. Organization. 1994;121.
  6. Carbajo  AE, Gomez  SM, Curto  SI, Schweigmann  NJ. Spatio-temporal variability in the transmission of dengue in Buenos Aires City [in Spanish]. Medicina (B Aires). 2004;64:2314.PubMed
  7. Presidencia de la Nación Argentina. Ministerio de Salud. Situación Dengue en Argentina y el Mercosur (1-Junio-07) [cited 2008 Mar 13]. Available from http://www.msal.gov.ar/htm/Site/portada.htm
  8. de Salud  M, de la Nación  P. El Instituto Maiztegui confirmó dos casos de fiebre amarilla en Misiones 17/3/08 [cited 2008 Mar 31]. Available from http://www.msal.gov.ar/htm/Site/noticias_plantilla.asp?Id=1206

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DOI: 10.3201/eid1409.080143

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Table of Contents – Volume 14, Number 9—September 2008

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Viviana Ritacco, Instituto Nacional de Enfermedades Infecciosas ANLIS “Carlos G. Malbrán,” Vélez Sarsfield 563, (1281) Ciudad de Buenos Aires, Argentina;

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Page created: July 13, 2010
Page updated: July 13, 2010
Page reviewed: July 13, 2010
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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