Volume 15, Number 1—January 2009
Research
Human Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Northern Vietnam, 2004–2005
Nguyen Duc Hien, Nguyen Hong Ha, Nguyen Tuong Van, Nguyen Thi Minh Ha, Trinh Thi Minh Lien, Nguyen Quoc Thai, Van Dinh Trang, Takuro Shimbo
, Yoshimitsu Takahashi, Yasuyuki Kato, Akihiko Kawana, Samu Akita, and Koichiro Kudo
, Yoshimitsu Takahashi, Yasuyuki Kato, Akihiko Kawana, Samu Akita, and Koichiro Kudo
Table 2
Initial laboratory and chest radiographic results for 29 patients infected with highly pathogenic avian influenza virus (H5N1), northern Vietnam, 2004–2005*
| Characteristic | Survived, median (interquartile range), n = 22 | Died, median (interquartile range), n = 7 | p value |
|---|---|---|---|
| Leukocytes, × 103/μL | 7.8 (7.1–12.0) | 3.4 (1.7–5.6)† | 0.0093 |
| Neutrophils, ×103/μL | 6.8 (4.8–9.9) | 2.3 (1.1–3.8)† | 0.0101 |
| Hemoglobin, g/L | 130 (107–137) | 121 (103–138) | 0.6102 |
| Platelets, × 103/μL | 214 (181–284) | 86 (38–139)† | 0.0101 |
| Albumin, g/L | 34.5 (31.2–35.1) | 21.7 (10.4–29.4)† | 0.0265 |
| AST, U/L | 45 (28–69) | 327 (77–352)† | 0.0077 |
| Total bilirubin, μmol/L | 10.3 (7.6–16.8) | 11.4 (7.0–27.1) | 0.7921 |
| Urea nitrogen, mmol/L |
4.5 (3.4–5.5) |
9 (3.4–14.3)† |
0.0462 |
| Initial chest radiographic findings‡ | |||
| No or slight lesion | 7 | 1 | 0.6510 |
| Moderate lesion | 10 | 3 | |
| Severe lesion | 5 | 3 |
*Not all laboratory findings and chest radiographic results were available. Results were derived from the following numbers of patients: complete blood count, 29; albumin 12; AST, 25; total bilirubin, 17; urea nitrogen, 27. AST, aspartate aminotransferase.
†p<0.05, by Wilcoxon test or Fisher exact test.
‡No or slight lesion, no lesion or localized (occupying less than one third of unilateral lung fields) in 1 lung; moderate, diffuse in 1 lung or localized but evident in both lungs; severe, diffuse in both lungs.
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