Volume 15, Number 1—January 2009
Human Infection with Highly Pathogenic Avian Influenza Virus (H5N1) in Northern Vietnam, 2004–2005
||Patient age, y, mean ± SD
||Leukocyte count, median, × 103/μL (IQR)
||Hospitalization after disease onset, median, d (IQR)
|Present study||2009||35.1 ± 14.4||7.2 (3.9–11.3)||6 (3.5–8)||22||7|
|Yuen at al (8). †||1998||17.6 ± 20.4||5.6 (2.47–10.7)||3 (2–4)||5||5|
|Tran et al. (4)||2004||13.7 ± 6.4||2.1 (1.9–2.8)||6 (5–7)||2||8|
|Chotpitayasunondh et al. (9)||2005||22.0 ± 21.4||4.43 (2.75–5.64)||NR||4||8|
|Oner et al. (19)||2006||10.1 ± 4.0||3.8 (1.8–5.75)||6 (4–7)||4||4|
|Kandun et al. (20)||2007||15.4 ± 14.9||3.59 (2.605–6.3)||7 (5–7)||4||4|
|Buchy et al. (21)||2007||16.0 ± 9.9||4.2 (3.6–4.7)||6 (5–7)||0||6|
*IQR, interquartile range; NR, not reported.
†Outcomes of 2 patients were not reported.
- Centers for Disease Control and Prevention. Isolation of avian influenza A(H5N1) viruses from humans—Hong Kong, May–December 1997. JAMA. 1998;279:263–4.
- Centers for Disease Control and Prevention. Update: isolation of avian influenza A(H5N1) viruses from humans—Hong Kong, 1997–1998. JAMA. 1998;279:347–8.
- Ku AS, Chan LT. The first case of H5N1 avian influenza infection in a human with complications of adult respiratory distress syndrome and Reye’s syndrome. J Paediatr Child Health. 1999;35:207–9.
- Tran TH, Nguyen TL, Nguyen TD, Luong TS, Pham PM, Nguyen VC, Avian influenza A (H5N1) in 10 patients in Vietnam. N Engl J Med. 2004;350:1179–88.
- World Health Organization. Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO, 2007. Geneva: The Organization [cited 2008 Oct 2]. Available from http://www.who.int/csr/disease/avian_influenza/country/cases_table_2007_09_10/en/index.html
- To KF, Chan PK, Chan KF, Lee WK, Lam WY, Wong KF, Pathology of fatal human infection associated with avian influenza A H5N1 virus. J Med Virol. 2001;63:242–6.
- de Jong MD, Simmons CP, Thanh TT, Hien VM, Smith GJ, Chau TN, Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med. 2006;12:1203–7.
- Yuen KY, Chan PK, Peiris M, Tsang DN, Que TL, Shortridge KF, Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus. Lancet. 1998;351:467–71.
- Chotpitayasunondh T, Ungchusak K, Hanshaoworakul W, Chunsuthiwat S, Sawanpanyalert P, Kijphati R, Human disease from influenza A (H5N1), Thailand, 2004. Emerg Infect Dis. 2005;11:201–9.
- Beigel JH, Farrar J, Han AM, Hayden FG, Hyer R, de Long MD, Avian influenza A (H5N1) infection in humans. N Engl J Med. 2005;353:1374–85.
- Gubareva LV, McCullers JA, Bethell RC, Webster RG. Characterization of influenza A/HongKong/156/97 (H5N1) virus in a mouse model and protective effect of zanamivir on H5N1 infection in mice. J Infect Dis. 1998;178:1592–6.
- Leneva IA, Roberts N, Govorkova EA, Goloubeva OG, Webster RG. The neuraminidase inhibitor GS4104 (oseltamivir phosphate) is efficacious against A/Hong Kong/156/97 (H5N1) and A/Hong Kong/1074/99 (H9N2) influenza viruses. Antiviral Res. 2000;48:101–15.
- Leneva IA, Goloubeva O, Fenton RJ, Tisdale M, Webster RG. Efficacy of zanamivir against avian influenza A viruses that possess genes encoding H5N1 internal proteins and are pathogenic in mammals. Antimicrob Agents Chemother. 2001;45:1216–24.
- Writing Committee of the Second World Health Organization Consultation on Clinical Aspects of Human Infection with Avian Influenza A (H5N1) Virus. Update on avian influenza A (H5N1) virus infection in humans. N Engl J Med. 2008;358:261–73.
- Schunemann HJ, Hill SR, Kakad M, Bellamy R, Uyeki TM, Hayden FG, WHO Rapid Advice Guidelines for pharmacological management of sporadic human infection with avian influenza A (H5N1) virus. Lancet Infect Dis. 2007;7:21–31.
- Mehta CR, Patel NR. Exact logistic regression: theory and examples. Stat Med. 1995;14:2143–60.
- Concato J, Feinstein AR, Holford TR. The risk of determining risk with multivariable models. Ann Intern Med. 1993;118:201–10.
- Peduzzi P, Concato J, Kemper E, Holford TR, Feinstein AR. A simulation study of the number of events per variable in logistic regression analysis. J Clin Epidemiol. 1996;49:1373–9.
- Oner AF, Arslan S, Akdeniz H, Sahin HA, Cesur Y, Epcacan S, Avian influenza A (H5N1) infection in eastern Turkey in 2006. N Engl J Med. 2006;355:2179–85.
- Kandun IN, Wibisono H, Sedyaningsih ER, Yusharmen, Hadisoedarsuno W, Purba W, et al. Three Indonesian clusters of H5N1 virus infection in 2005. N Engl J Med. 2006;355:2186–94.
- Buchy P, Mardy S, Vong S, Toyoda T, Aubin JT, Miller M, Influenza A/H5N1 virus infection in humans in Cambodia. J Clin Virol. 2007;39:164–8.
- World Health Organization. Epidemiology of WHO-confirmed human cases of avian influenza A(H5N1) infection. Wkly Epidemiol Rec. 2006;81:249–60.
- Govorkova EA, Rehg JE, Krauss S, Yen HL, Guan Y, Peiris M, Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004. J Virol. 2005;79:2191–8.
- Yen HL, Monto AS, Webster RG, Govorkova EA. Virulence may determine the necessary duration and dosage of oseltamivir treatment for highly pathogenic A/Vietnam/1203/04 influenza virus in mice. J Infect Dis. 2005;192:665–72.
- Salomon R, Hoffmann E, Webster RG. Inhibition of the cytokine response does not protect against lethal H5N1 influenza infection. Proc Natl Acad Sci U S A. 2007;104:12479–81.
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