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Volume 15, Number 2—February 2009
Dispatch

European Bat Lyssavirus Transmission among Cats, Europe

Laurent DacheuxComments to Author , Florence Larrous, Alexandra Mailles, Didier Boisseleau, Olivier Delmas, Charlotte Biron, Christiane Bouchier, Isabelle Capek, Michel Muller, Frédéric Ilari, Tanguy Lefranc, François Raffi, Maryvonne Goudal, and Hervé Bourhy
Author affiliations: Institut Pasteur, Paris, France (L. Dacheux, F. Larrous, O. Delmas, C. Bouchier, M. Goudal, H. Bourhy); Institut de Veille Sanitaire, Saint-Maurice, France (A. Mailles, I. Capek); Direction Départementale des Services Vétérinaires de la Vendée, La Roche-sur-Yon, France (D. Boisseleau); Centre Hospitalier Universitaire de Nantes, Nantes, France (C. Biron, F. Raffi); Clinique Vétérinaire du Bas-Poitou, Fontenay-le-Comte, France (M. Muller); Clinique Vétérinaire Roosevelt, Vannes, France (F. Ilari, T. Lefranc)

Main Article

Table 2

Percentage nucleotide divergence between EBLV-1a strains isolated from a cat (07240FRA) and bats (08120FRA, 03002FRA, and RV9)*

Gene Sequence Strain
07240FRA/08120FRA 07240FRA/03002FRA 07240FRA/RV9
Complete genome nt 0.1 (12) 0.4 (36) 2 (226)
Nucleoprotein nt 0 0.2 (2) 1.5 (19)
aa 0 0 0
Phosphoprotein nt 0.1 (1) 0.4 (4) 2.3 (23)
aa 0.3 (1), I149T 0.7 (2), I149T, G175D 1.7 (7), Q147R, I149T, T156A, F169S, P174L, G175D, G266S
Matrix nt 0 0.3 (2) 1.5 (7)
aa 0 0 1 (2), N2K, I155M
Glycoprotein nt 0 0.2 (3) 2.1 (32)
aa 0 0.2 (1), S489P 0.8 (4), L244Q, S278N, S489P, A521T
Polymerase nt 0.03 (2) 0.3 (16) 1.9 (109)
aa 0 0.2 (4), A97T, G1160D, T1754I, R1894S 0.3 (5), R315K, I391V, K980R, T1754I, R1894S

*Strains 07240FRA and 08120FRA were isolated from cat no. 2 and from a bat (Eptesicus serotinus) found dead in the same area (Fontenay-le-Comte, France), respectively. Strain 03002FRA was isolated from another bat (E. serotinus) collected ≈100 km from Fontenay-le-Comte in 2003 (10). Isolate RV9 was collected from a bat (E. serotinus) in 1968 in Germany (15). Numbers of substitutions are indicated in parentheses. Type of amino acid substitutions are indicated in boldface. GenBank accession numbers for full-length genomic sequences corresponding to strains 07240FRA, 08120FRA, 03002FRA, and RV9 are EU626552, EU626551, EU293109, and EF157976, respectively. EBLV, European bat lyssavirus; nt, nucleotide; aa, amino acid.

Main Article

References
  1. Bourhy  H, Dacheux  L, Strady  C, Mailles  A. Rabies in Europe in 2005. Euro Surveill. 2005;10:213–6.PubMedGoogle Scholar
  2. Davis  PL, Holmes  EC, Larrous  F, Van der Poel  WH, Tjørnehøj  K, Alonso  WJ, Phylogeography, population dynamics, and molecular evolution of European bat lyssaviruses. J Virol. 2005;79:10487–97. DOIPubMedGoogle Scholar
  3. Harris  SL, Brookes  SM, Jones  G, Hutson  AM, Racey  PA, Aegerter  J, European bat lyssaviruses: distribution, prevalence and implications for conservation. Biol Conserv. 2006;131:193–210. DOIGoogle Scholar
  4. Vos  A, Kaipf  I, Denzinger  A, Fooks  AR, Johnson  N, Müller  T. European bat lyssaviruses: an ecological enigma. Acta Chiropt. 2007;9:283–96. DOIGoogle Scholar
  5. Amengual  B, Bourhy  H, López-Roig  M, Serra-Cobo  J. Temporal dynamics of European bat lyssavirus type 1 and survival of Myotis myotis bats in natural colonies. PLoS One. 2007;2:e566. DOIPubMedGoogle Scholar
  6. Tjørnehøj  K, Fooks  AR, Agerholm  JS, Rønsholt  L. Natural and experimental infection of sheep with European bat lyssavirus type-1 of Danish bat origin. J Comp Pathol. 2006;134:190–201. DOIPubMedGoogle Scholar
  7. Müller  T, Cox  J, Peter  W, Schäfer  R, Johnson  N, McElhinney  LM, Spill-over of European bat lyssavirus type 1 into a stone marten (Martes foina) in Germany. J Vet Med B Infect Dis Vet Public Health. 2004;51:49–54. DOIPubMedGoogle Scholar
  8. World Health Organization. WHO expert consultation on rabies. World Health Organ Tech Rep Ser. 2005;931:1–88.PubMedGoogle Scholar
  9. Xu  G, Weber  P, Hu  Q, Xue  H, Audry  L, Li  C, A simple sandwich ELISA (WELYSSA) for the detection of lyssavirus nucleocapsid in rabies suspected specimens using mouse monoclonal antibodies. Biologicals. 2007;35:297–302. DOIPubMedGoogle Scholar
  10. Delmas  O, Holmes  EC, Talbi  C, Larrous  F, Dacheux  L, Bouchier  C, Genomic diversity and evolution of the lyssaviruses. PLoS One. 2008;3:e2057. DOIPubMedGoogle Scholar
  11. Conseil Supérieur d’Hygiène Publique de France (CSHPF). Recommandations pour limiter l’exposition du public aux virus de la rage des chauves-souris. Bulletin Epidémiologique Hebdomadaire. 2001;39:193.
  12. Takumi  K, Lina  PH, van der Poel  WH, Kramps  JA, van der Giessen  JW. Public health risk analysis of European bat lyssavirus infection in The Netherlands. Epidemiol Infect. 2008;21:1–7. DOIGoogle Scholar
  13. Tjørnehøj  K, Rønsholt  L, Fooks  AR. Antibodies to EBLV-1 in a domestic cat in Denmark. Vet Rec. 2004;155:571–2.PubMedGoogle Scholar
  14. Brookes  SM, Klopfleisch  R, Müller  T, Healy  DM, Teifke  JP, Lange  E, Susceptibility of sheep to European bat lyssavirus type-1 and -2 infection: a clinical pathogenesis study. Vet Microbiol. 2007;125:210–23. DOIPubMedGoogle Scholar
  15. Marston  DA, McElhinney  LM, Johnson  N, Müller  T, Conzelmann  KK, Tordo  N, Comparative analysis of the full genome sequence of European bat lyssavirus type 1 and type 2 with other lyssaviruses and evidence for a conserved transcription termination and polyadenylation motif in the G-L 3′ non-translated region. J Gen Virol. 2007;88:1302–14. DOIPubMedGoogle Scholar

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