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Volume 15, Number 2—February 2009


European Bat Lyssavirus Transmission among Cats, Europe

Laurent DacheuxComments to Author , Florence Larrous, Alexandra Mailles, Didier Boisseleau, Olivier Delmas, Charlotte Biron, Christiane Bouchier, Isabelle Capek, Michel Muller, Frédéric Ilari, Tanguy Lefranc, François Raffi, Maryvonne Goudal, and Hervé Bourhy
Author affiliations: Institut Pasteur, Paris, France (L. Dacheux, F. Larrous, O. Delmas, C. Bouchier, M. Goudal, H. Bourhy); Institut de Veille Sanitaire, Saint-Maurice, France (A. Mailles, I. Capek); Direction Départementale des Services Vétérinaires de la Vendée, La Roche-sur-Yon, France (D. Boisseleau); Centre Hospitalier Universitaire de Nantes, Nantes, France (C. Biron, F. Raffi); Clinique Vétérinaire du Bas-Poitou, Fontenay-le-Comte, France (M. Muller); Clinique Vétérinaire Roosevelt, Vannes, France (F. Ilari, T. Lefranc)

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Table 2

Percentage nucleotide divergence between EBLV-1a strains isolated from a cat (07240FRA) and bats (08120FRA, 03002FRA, and RV9)*

Gene Sequence Strain
07240FRA/08120FRA 07240FRA/03002FRA 07240FRA/RV9
Complete genome nt 0.1 (12) 0.4 (36) 2 (226)
Nucleoprotein nt 0 0.2 (2) 1.5 (19)
aa 0 0 0
Phosphoprotein nt 0.1 (1) 0.4 (4) 2.3 (23)
aa 0.3 (1), I149T 0.7 (2), I149T, G175D 1.7 (7), Q147R, I149T, T156A, F169S, P174L, G175D, G266S
Matrix nt 0 0.3 (2) 1.5 (7)
aa 0 0 1 (2), N2K, I155M
Glycoprotein nt 0 0.2 (3) 2.1 (32)
aa 0 0.2 (1), S489P 0.8 (4), L244Q, S278N, S489P, A521T
Polymerase nt 0.03 (2) 0.3 (16) 1.9 (109)
aa 0 0.2 (4), A97T, G1160D, T1754I, R1894S 0.3 (5), R315K, I391V, K980R, T1754I, R1894S

*Strains 07240FRA and 08120FRA were isolated from cat no. 2 and from a bat (Eptesicus serotinus) found dead in the same area (Fontenay-le-Comte, France), respectively. Strain 03002FRA was isolated from another bat (E. serotinus) collected ≈100 km from Fontenay-le-Comte in 2003 (10). Isolate RV9 was collected from a bat (E. serotinus) in 1968 in Germany (15). Numbers of substitutions are indicated in parentheses. Type of amino acid substitutions are indicated in boldface. GenBank accession numbers for full-length genomic sequences corresponding to strains 07240FRA, 08120FRA, 03002FRA, and RV9 are EU626552, EU626551, EU293109, and EF157976, respectively. EBLV, European bat lyssavirus; nt, nucleotide; aa, amino acid.

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