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Volume 15, Number 3—March 2009


Clinical Risk Factors for Severe Clostridium difficile–associated Disease

Timothy J. HenrichComments to Author , Douglas Krakower, Asaf Bitton, and Deborah S. Yokoe
Author affiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (T.J. Henrich, D. Krakower, A. Bitton, D.S. Yokoe); Massachusetts General Hospital, Boston (D. Krakower); Harvard Medical School, Boston (Deborah S. Yokoe)

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Table 4

Binary logistic regression model to identify variables independently associated with severe CDAD, 336 patients*

Variable OR 95% CI
Age >70 y 3.35† 1.48–7.57
Female 0.93 0.42–2.03
Antimicrobial-drug use 1.76 0.60–5.21
Malignancy 0.73 0.33–1.65
Immunocompromised 0.38 0.07–1.96
Small bowel obstruction or ileus 3.06‡ 1.00–9.39
Abnormal abdominal CT scan 13.54† 5.72–32.07
Prior hospitalization 1.39 0.61–3.18
SNF/rehabilitation stay 1.11 0.46–2.68

*CDAD, Clostridium difficile–associated disease; OR, odds ratio; CI, confidence interval; CT, computed tomography; SNF, skilled-nursing facility. Constant included in analysis.
‡p = 0.05.

Main Article