Volume 15, Number 7—July 2009
Research
Clusters of Multidrug-Resistant Mycobacterium tuberculosis Cases, Europe
Isabelle Devaux
, Kristin Kremer, Herre Heersma, and Dick van Soolingen
, Kristin Kremer, Herre Heersma, and Dick van Soolingen
Table 4
Predictors for clustered MDR TB strains compared with unique strains among 521 cases reported in 16 European countries, January 2003 through June 2007*
| Variable | MDR TB strains |
Unadjusted OR (95% CI) | Adjusted† OR (95% CI) | |
|---|---|---|---|---|
| No. patients | % Clustered | |||
| Sex | ||||
| Male | 347 | 48 | 1 | 1 |
| Female |
170 |
49 |
1.0 (0.7–1.5) |
1.1 (0.6–1.9) |
| Age | ||||
| 15–44 | 324 | 43 | 1 | 1 |
| 45–64 | 143 | 61 | 2.1 (1.4–3.1) | 1.3 (0.7–2.3) |
| >65 |
36 |
53 |
1.5 (0.7–3.0) |
2.8 (0.8–9.4) |
| Origin | ||||
| Baltic states | 188 | 81 | 21.9 (10.6–44.9) | 25.1 (9.9–64.0) |
| Other FSU countries‡ | 99 | 61 | 7.7 (3.7–16.1) | 8.7 (3.2–23.2) |
| Other European countries | 72 | 17 | 1 | 1 |
| Africa |
71 |
24 |
1.6 (0.7–3.6) |
1.1 (0.4–3.5) |
| Site of disease | ||||
| Pulmonary | 473 | 50 | 2.4 (1.2–4.9) | 0.5 (0.2–1.6) |
| Extrapulmonary |
41 |
29 |
1 |
1 |
| Previous TB | ||||
| Yes | 163 | 54 | 1.0 (0.6–1.4) | 1.1 (0.6–1.9) |
| No |
248 |
55 |
1 |
1 |
| XDR TB | ||||
| Yes | 51 | 82 | 4.1 (1.9–8.7) | _ |
| No | 341 | 53 | 1 | – |
*TB, tuberculosis; MDR, multidrug-resistant; OR, odds ratio; CI, confidence interval; FSU, former Soviet Union; XDR, extensively drug-resistant. Boldface indicates significance.
†For all other factors in the model except XDR TB.
‡Former Soviet Union countries: Azerbaijan, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, Russia, Tajikistan, Ukraine, and Uzbekistan.
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