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Volume 15, Number 7—July 2009


Relapse Associated with Active Disease Caused by Beijing Strain of Mycobacterium tuberculosis1

William J. BurmanComments to Author , Erin E. Bliven, Lauren S. Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, Andrew Vernon, and for the Tuberculosis Trials Consortium
Author affiliations: Denver Public Health, Denver Colorado, USA (W.J. Burman); University of Colorado at Denver Health Sciences Center, Denver (W.J. Burman); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E.E. Bliven, L. Cowan, L. Bozeman, L. Diem, A. Vernon); The University of California, San Francisco, California, USA (P. Nahid)

Main Article

Table 2

Association between treatment failure or relapse and active disease caused by Beijing vs. other genotypes of Mycobacterium tuberculosis, Tuberculosis Trials Consortium Study 22*

Outcome Disease caused by Beijing genotype, n = 57 Disease caused by other genotype, n = 303 Odds ratio (95% CI) p value
Cure (n = 296)
42 (14)
254 (86)
1.9 (0.9–3.6)
Failure or relapse (n = 64) 15 (23) 49 (77)
Failure (n = 8) 1 (13) 7 (88) 0.9 (0.1–6.3) 1.00
Relapse (n = 56) 14 (25) 42 (75) 2.0 (1.0–4.0) 0.04

*The Tuberculosis Trials Consortium Study enrolled patients during 1995–1998. Participants in the case–control study were selected from among 1,004 HIV-infected participants. CI, confidence interval.

Main Article

1This study was presented in part at the 2008 International Conference of the American Thoracic Society, May 16–21, 2008, Toronto, Ontario, Canada.