Volume 15, Number 7—July 2009
Research
Relapse Associated with Active Disease Caused by Beijing Strain of Mycobacterium tuberculosis1
William J. Burman
, Erin E. Bliven, Lauren S. Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, Andrew Vernon, and for the Tuberculosis Trials Consortium
, Erin E. Bliven, Lauren S. Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, Andrew Vernon, and for the Tuberculosis Trials Consortium
Table 2
Association between treatment failure or relapse and active disease caused by Beijing vs. other genotypes of Mycobacterium tuberculosis, Tuberculosis Trials Consortium Study 22*
| Outcome | Disease caused by Beijing genotype, n = 57 | Disease caused by other genotype, n = 303 | Odds ratio (95% CI) | p value |
|---|---|---|---|---|
| Cure (n = 296) |
42 (14) |
254 (86) |
1.9 (0.9–3.6) |
0.07 |
| Failure or relapse (n = 64) | 15 (23) | 49 (77) | ||
| Failure (n = 8) | 1 (13) | 7 (88) | 0.9 (0.1–6.3) | 1.00 |
| Relapse (n = 56) | 14 (25) | 42 (75) | 2.0 (1.0–4.0) | 0.04 |
*The Tuberculosis Trials Consortium Study enrolled patients during 1995–1998. Participants in the case–control study were selected from among 1,004 HIV-infected participants. CI, confidence interval.
1This study was presented in part at the 2008 International Conference of the American Thoracic Society, May 16–21, 2008, Toronto, Ontario, Canada.
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