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Volume 15, Number 7—July 2009


Relapse Associated with Active Disease Caused by Beijing Strain of Mycobacterium tuberculosis1

William J. BurmanComments to Author , Erin E. Bliven, Lauren S. Cowan, Lorna Bozeman, Payam Nahid, Lois Diem, Andrew Vernon, and for the Tuberculosis Trials Consortium
Author affiliations: Denver Public Health, Denver Colorado, USA (W.J. Burman); University of Colorado at Denver Health Sciences Center, Denver (W.J. Burman); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (E.E. Bliven, L. Cowan, L. Bozeman, L. Diem, A. Vernon); The University of California, San Francisco, California, USA (P. Nahid)

Main Article

Table 3

Association between active disease caused by a Beijing genotype of Mycobacterium tuberculosis and relapse, adjusted for clinical risk factors, Tuberculosis Trials Consortium Study 22*

Characteristic Univariate analysis
Multivariate analysis
Odds ratio (95% CI) p value Odds ratio (95% CI) p value
Infected with Beijing genotype 2.0 (1.0–4.0) 0.05 2.2 (1.0–4.9) 0.07
Non-Hispanic white race/ethnicity 3.3 (1.7–6.1) <0.01 3.0 (1.4–6.7) <0.01
Underweight at tuberculosis diagnosis 4.7 (2.6–8.6) <0.01 3.7 (1.8–7.2) <0.01
Pulmonary cavitation 5.0 (2.4–10.7) <0.01 3.2 (1.4–7.5) 0.01
Bilateral pulmonary disease 2.9 (1.5–5.7) <0.01 1.8 (0.9–4.0) 0.12
Two-month sputum culture positivity 4.7 (2.6–8.7) <0.01 2.4 (1.2–4.9) 0.01

*The Tuberculosis Trials Consortium Study enrolled patients during 1995–1998. Participants in the case–control study were selected from among 1,004 HIV-infected participants. CI, confidence interval.

Main Article

1This study was presented in part at the 2008 International Conference of the American Thoracic Society, May 16–21, 2008, Toronto, Ontario, Canada.