Volume 16, Number 11—November 2010
Dispatch
Reassortment of Ancient Neuraminidase and Recent Hemagglutinin in Pandemic (H1N1) 2009 Virus
Priyasma Bhoumik and Austin L. Hughes
Table 2
Mean ± SE gene diversity at synonymous and nonsynonymous polymorphic nucleotide sites in hemagglutinin and neuraminidase genes of influenza A virus serotypes*
| Genotype | HA | NA | |||
|---|---|---|---|---|---|
| Synonymous | Nonsynonymous | Synonymous | Nonsynonymous | ||
| Pandemic H1N1 (2009) | 0.0120 ± 0.0007 [173] | 0.0112 ± 0.0006 [839] | 0.2535 ± 0.0173 [179] | 0.0863 ± 0.0060 [706]† | |
| H1N1 (pre-2009) | 0.0798 ± 0.0063 [198] | 0.0506 ± 0.0019 [814]† | 0.0765 ± 0.0083 [152] | 0.0453 ± 0.0017 [712]† | |
| H3N2 | 0.0710 ± 0.0086 [203] | 0.0331 ± 0.0030 [793]† | 0.0760 ± 0.0087 [177] | 0.0332 ± 0.0029 [688]† | |
| H5N1 | 0.1195 ± 0.0106 [184] | 0.0552 ± 0.0027 [834]† | 0.1120 ± 0.0098 [157] | 0.0482 ± 0.0024 [645]†
*HA, hemagglutinin; NA, neuraminidase. Numbers of polymorphic nucleotide sites are indicated in brackets. | |
*HA, hemagglutinin; NA, neuraminidase. Numbers of polymorphic nucleotide sites are indicated in brackets.
†Gene diversity at nonsynonymous sites significantly different from that at synonymous sites (p<0.001; randomization test).
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