Volume 18, Number 1—January 2012
Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses
|NA mutation||Mean ± SD level of destabilization, kcal/mol†|
|H275Y||4.7 ± 0.4|
|H275Y + I117V||5.2 ± 0.4|
|H275Y + I117M||5.0 ± 0.3|
|I117V||0.5 ± 0.02|
|I117M||0.1 ± 0.1|
†Calculated with FoldX (11) on the basis of 5 repetitions.
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