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Volume 18, Number 1—January 2012


Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Aeron C. HurtComments to Author , Sook Kwan Leang, David J. Speers, Ian G. Barr, and Sebastian Maurer-Stroh
Author affiliations: World Health Organization Collaborating Centre for Reference and Research on Influenza, North Melbourne, Victoria, Australia (A.C. Hurt, S.K. Leang, I.G. Barr); PathWest Laboratory Medicine, Nedlands, Western Australia, Australia (D.J. Speers); Agency for Science, Technology and Research, Singapore (S. Maurer-Stroh); Ministry of Health, Singapore (S. Maurer-Stroh); Nanyang Technological University, Singapore (S. Maurer-Stroh)

Main Article

Table 2

Predicted local structure destabilization for the different NA mutations from pandemic (H1N1) 2009 viruses*

NA mutation Mean ± SD level of destabilization, kcal/mol†
H275Y 4.7 ± 0.4
H275Y + I117V 5.2 ± 0.4
H275Y + I117M 5.0 ± 0.3
I117V 0.5 ± 0.02
I117M 0.1 ± 0.1

*NA, neuraminidase.
†Calculated with FoldX (11) on the basis of 5 repetitions.

Main Article