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Volume 18, Number 10—October 2012
Research

WU and KI Polyomaviruses in Respiratory Samples from Allogeneic Hematopoietic Cell Transplant Recipients

Jane Kuypers1Comments to Author , Angela P. Campbell1, Katherine A. Guthrie, Nancy L. Wright, Janet A. Englund, Lawrence Corey, and Michael Boeckh
Author affiliations: University of Washington, Seattle, Washington, USA (J. Kuypers, A.P. Campbell, N.L. Wright, J.A. Englund, L. Corey, M. Boeckh); Fred Hutchinson Cancer Research Center, Seattle (J. Kuypers, A.P. Campbell, K.A. Guthrie, J.A. Englund, L. Corey, M. Boeckh); and Seattle Children’s Hospital, Seattle (A.P. Campbell, J.A. Englund)

Main Article

Table 2

Characteristics of 222 HCT recipients tested for KIPyV or WUPyV*

Characteristic No. (%) recipients
All, n = 222 Infected with either virus, n = 62 Not infected, n = 160
Age, y

<20

 23 (10) 18 (29) 5 (3)

20–39

 37 (17) 14 (23) 23 (14)

40–59

 99 (45) 17 (27) 82 (51)

>60

 63 (28) 13 (21) 50 (31)
Sex

F

 87 (39) 23 (37) 64 (40)

M

 135 (61) 39 (63) 96 (60)
Underlying disease risk†

Standard

 142 (64) 40 (65) 102 (64)

High

 80 (36) 22 (35) 58 (36)
Stem cell source

Bone marrow

 28 (13) 12 (19) 16 (10)

Peripheral blood

 179 (81) 47 (76) 132 (83)

Cord blood

 15 (7) 3 (5) 12 (8)
CMV serostatus

D+/R+

 56 (25) 17 (27) 39 (24)

D+/R–

 81 (36) 22 (35) 59 (37)

D–/R+

 16 (7) 4 (6) 12 (8)

D–/R–

 69 (31) 19 (31) 50 (31)
Donor match

Related–matched

 77 (35) 23 (37) 54 (34)

Related–mismatched

 9 (4) 6 (10) 3 (2)

Unrelated–cord blood

 15 (7) 3 (5) 12 (8)

Unrelated–matched

 97 (44) 24 (39) 73 (46)

Unrelated–mismatched

 24 (11) 6 (10) 18 (11)
Conditioning regimen

Myeloablative

 128 (58) 41 (66) 87 (54)

Nonmyeloablative

 94 (42) 21 (34) 73 (46)
Acute graft-versus-host disease

Grade 0 or 1

 78 (35) 30 (48) 48 (30)

Grade 2–4

 144 (65) 32 (52) 112 (70)

*HCT, hematopoietic cell transplantation; KIPyV, KI polyomavirus; WUPyV, WU polyomavirus; CMV, cytomegalovirus; D, donor; R, recipient.
†The underlying disease stage of a patient was categorized as low, intermediate, or high risk (29,31).

Main Article

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Main Article

1These authors contributed equally to this article.

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Page updated: September 13, 2012
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