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Volume 18, Number 11—November 2012


Lack of Evidence for Zoonotic Transmission of Schmallenberg Virus

Chantal Reusken1Comments to Author , Cees van den Wijngaard1, Paul van Beek, Martin Beer, Ruth Bouwstra, Gert-Jan Godeke, Leslie Isken, Hans van den Kerkhof, Wilfrid van Pelt, Wim van der Poel, Johan Reimerink, Peter Schielen, Jonas Schmidt-Chanasit, Piet Vellema, Ankje de Vries, Inge Wouters, and Marion Koopmans
Author affiliations: National Institute for Public Health and the Environment, Bilthoven, the Netherlands (C. Reusken, C. van den Wijngaard, P. van Beek, G.-J. Godeke, L. Isken, H. van den Kerkhof, W. van Pelt, J. Reimerink, P. Schielen, A. de Vries, M. Koopmans); Friedrich-Loeffler-Institut, Insel Riems, Germany (M. Beer); Central Veterinary Institute of Wageningen University and Research Centre, Lelystad, the Netherlands (R. Bouwstra, W. van der Poel); Bernhard Nocht Institute for Tropical Medicine, Hamburg (J. Schmidt-Chanasit); Animal Health Service, Deventer, the Netherlands (P. Vellema); and Institute for Risk Assessment Sciences, Utrecht, the Netherlands (I. Wouters)

Main Article

Table 1

Probability of detecting at least 1 seropositive sample among different sample sizes and hypothetical seroprevalences in study to determine whether Schmallenberg virus can be zoonotically transmitted, the Netherlands

Sample size Hypothetical seroprevalence, % Probability* of detecting at least 1 seropositive, %
50 2.00 63.58
100 2.00 86.74
150 2.00 95.17
192 2.00 97.93
200 2.00 98.24
301 2.00 99.77
301 1.00 95.14
301 0.50 77.88
301 0.25 52.93
301 3.00 99.99

*The probability was calculated as 1 – (1 – seroprevalence) × sample size, so for a seroprevalence of 2% and a sample size of 200 the probability of detecting at least 1 seropositive = 1 – (1 – 0.02) × 200.

Main Article

1These authors contributed equally to this article.