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Volume 18, Number 12—December 2012
Research

Diagnostic Assays for Crimean-Congo Hemorrhagic Fever

Jessica VanhomwegenComments to Author , Maria João Alves, Tatjana Avšič Županc, Silvia Bino, Sadegh Chinikar, Helen Karlberg, Gülay Korukluoğlu, Miša Korva, Masoud Mardani, Ali Mirazimi, Mehrdad Mousavi, Anna Papa, Ana Saksida, Batool Sharifi-Mood, Persofoni Sidira, Katerina Tsergouli, Roman Wölfel, Hervé Zeller, and Philippe Dubois
Author affiliations: Author affiliations: Institut Pasteur, Paris, France (J. Vanhomwegen, P. Dubois); European Centre for Disease Control, Stockholm, Sweden (J. Vanhomwegen, H. Zeller); National Institute of Health Dr. Ricardo Jorge, Lisbon, Portugal (M.J. Alves); Faculty of Medicine, Ljubljana, Slovenia (T. Avšič Županc, M. Korva, A. Saksida); Institute of Public Health, Tirana, Albania (S. Bino); Pasteur Institute of Iran, Tehran, Iran (S. Chinikar); Swedish Institute for Infectious Disease Control, Solna, Sweden (H. Karlberg, A. Mirazimi, M. Mousavi); Refik Saydam National Public Health Agency, Ankara, Turkey (G. Korukluoğlu); Shahid Beheshti University of Medical Sciences, Tehran, Iran (M. Mardani, B. Sharifi-Mood); Aristotle University of Thessaloniki, Thessaloniki, Greece (A. Papa, P. Sidira, K. Tsergouli); and Bundeswehr Institute of Microbiology, Munich, Germany (R. Wölfel)

Main Article

Table 3

Patient characteristics and sample storage information for samples tested for CCHFV

CCHFV positive, n = 66 CCHFV negative, n = 73 CCHFV positive, n = 54 CCHFV negative, n = 21
Conditions

CCHF

 66 (100.0) 0 54 (100.0) 0

Brucellosis

 0 2 (2.7) 0 2 (9.5)

Chikungunya

 0 1 (1.4) 0 1 (4.8)

HFRS

 0 13 (17.8) 0 7 (33.3)

Leptospirosis

 0 13 (17.8) 0 3 (14.3)

Q fever

 0 1 (1.4) 0 1 (4.8)

Tularemia

 0 1 (1.4) 0 1 (4.8)

West Nile fever

 0 1 (1.4) 0 1 (4.8)

Healthy or non-CCHF

 0 41 (56.2) 0 5 (23.8)
Patient country of origin

Albania

 9 (13.6) 0 8 (14.8) 0

Germany

 0 23 (31.5) 0 7 (33.3)

Greece

 0 9 (12.3) 0 9 (42.9)

Iran

 32 (48.5) 0 31 (57.4) 0

Kosovo

 21 (31.8) 20 (27.4) 7 (13.0) 4 (19.0)

Portugal

 0 20 (27.4) 0 0

Sub-Saharan Africa

 4 (6.1) 0 0 0

Turkey

 0 1 (1.4) 8 (14.8) 1 (4.8)
CCHF disease severity

Moderate

 49 (74.2) 0 37 (68.5) 0

Severe

 11 (16.7) 0 2 (3.7) 0

Fatal

 3 (4.5) 0 6 (11.1) 0

Asymptomatic

 3 (4.5) 0 7 (13.0) 0

Unknown

 0 0 2 (3.7) 0
Length of illness, d

<15 d

 46 (69.7) 0 43 (79.6) 0

≥15 d

 12 (18.2) 0 0 0

Asymptomatic

 3 (4.5) 0 7 (13.0) 0

Unknown

 5 (7.6) 0 4 (7.4) 0
Sample storage time, y

<10

 49 (74.2) 64 (87.7) 54 (100.0) 10 (47.6)

≥10

 17 (25.8) 0 0 2 (9.5)

Unknown

 0 9 (12.3) 0 9 (42.9)
Sample storage temperature, °C

−80

 34 (51.5) 49 (67.1) 9 (16.7) 4 (19.1)

−70

 32 (48.5) 0 45 (83.3) 9 (42.9)

−20

 0 24 (32.9) 0 8 (38.1)

*CCHF, Crimean-Congo hemorrhagic fever; CCHFV, CCHF virus; HFRS, hemorrhagic fever with renal syndrome.

Main Article

Page created: November 21, 2012
Page updated: November 21, 2012
Page reviewed: November 21, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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