Volume 18, Number 2—February 2012
Dispatch
Disseminated Infection Caused by Novel Species of Microsporidium, Thailand
Chusana Suankratay
, Ekkachai Thiansukhon, Voraphoj Nilaratanakul, Chaturong Putaporntip, and Somchai Jongwutiwes
, Ekkachai Thiansukhon, Voraphoj Nilaratanakul, Chaturong Putaporntip, and Somchai Jongwutiwes
Table A1
Characteristics of 12 patients with microsporidial myositis*
| Patient no. | Age/sex | Country | Year | Clinical features | Illness duration | Tissues and organs involved | HIV status | CD4 count/μL | Species | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 4 mo/M | United States | 1973 | Fever, weakness | 4 mo | Heart and striated muscle | NA | NA | Brachiola connori | NA | Died |
| 2 | 20 y/M | United States | 1985 | Fever, weakness, lympadenopathy, testicular atrophy, gynecomastia, sinusitis | 7 mo | Striated muscle | – | NA | Pleistophora raronneafiei | CTX | Survived >4 mo |
| 3 | 33 y/M | Haiti | 1993 | Fever, weakness, weight loss, co-infected with Norcardia sp. | 2 mo | Heart and striated muscle | AIDS | NA | Trachipliestophora sp. | PYM | Died |
| 4 | 35 y/M | The Gambia | 1996 | Fever, weakness, anemia | NA | Striated muscle | AIDS | 57 | Trachipliestophora sp. | CLI | NA |
| 5 | 34 y/M | Australia | 1996 | Fever, weakness, keratitis, sinusitis | 3 mo | Striated muscle, cornea, sinus | AIDS | 6 | T. hominis | NA | Partial recovery; died of HIV infection |
| 6 | 33 y/M | United States | 1996 | Fever, hemiparesis, seizures | 2 mo | Heart, striated muscle, brain, bone, viscera | AIDS | 2 | T. anthropophthera | ABZ, PYM, SDZ | Died |
| 7 | 8 y/F | United States | 1996 | Weakness, seizures, aphasia, dyspnea | 4 mo | Heart, striated muscle, brain, bone, viscera | AIDS | NA | T. anthropophthera | Agents for toxoplasmosis | Died |
| 8 | 31 y/M | United States | 1998 | Fever, weakness | 5 mo | Striated muscle | AIDS | 35 | B. vesicularum | PYM, SDZ, ABZ, ITZ | Complete recovery, died of viral pneumonitis |
| 9 | 67 y/F | United States | 2004 | Fever, weakness, co-infected with Pneumocystis sp.) | 6 wk | Striated muscle | – | NA | B. algerae | ABZ, CLI, ATQ, ITZ | Died |
| 10 | 47 y/M | Australia | 2005 | Weakness, co-infected with Burkholderia pseudomallei, MAC infections | NA | Striated muscle | AIDS | 30 | T. hominis | None | Suicide |
| 11 | 67 y/F | United States | 2011 | Fever, tongue lesions | 5 mo | Striated muscle | – | NA | Tubulinosema acridophagus | ABZ | Died of CLL |
| 12 | 43 y/M | Thailand | 2011 | Fever, weakness, pulmonary hypertension | 15 mo | Striated muscle, bone marrow, kidney, bladder | – | 368 | Microsporidium sp. | ABZ | Died of aspiration pneumonia |
*NA, not available, –, negative; CTX, cotrimoxazole; PYM, pyrimethamine; CLI, clindamycin; ABZ, albendazole; SDZ, sulfadiazine; ITZ, itraconazole; ATQ, atovaquone; MAC, Mycobacterium avium complex; CLL, chronic lyphocytic leukemia.
Page created: January 09, 2012
Page updated: January 10, 2012
Page reviewed: January 10, 2012
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