Volume 18, Number 5—May 2012
Research
Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011
Table A1
Amino acid differences between WNV prototype Kunjin MRM61C, NY99, and NSW11 strains*
Polyprotein and aa position in polyprotein (position in individual protein) | WNV strain (GenBank accession no.) |
No. aa differences† | ||
---|---|---|---|---|
MRM61C AY274504.1) | NY99 4132 (HQ596519) | NSW2011 (JN887352) | ||
C | ||||
28 | T | I | I | |
41 | R | K | R | 2(0):2(2):4(2) |
44 | T | I | I | |
71 | S | G | S | |
PrM | ||||
108(3) | K | K | R | |
113(8) | F | V | F | |
114(9) | M | M | T | |
120(15) | G | S | G | |
143(38) | T | T | A | 6(5):10(7):7(3) |
145(40) | I | V | I | |
158(53) | I | I | T | |
166(61) | H | Y | Y | |
195(90) | L | S | L | |
228(123) | S | A | S | |
279(174) | A | V | T | |
E | ||||
334(44) | K | K | R | |
357(67) | E | D | E | |
379(89) | S | A | S | |
383(93) | K | R | K | |
416(126) | T | I | T | |
446(156) | F | S | S | |
449(159) | T | V | T | 3(1):15(7):14(8) |
452(162) | A | T | A | |
489(199) | S | N | S | |
519(229) | E | G | E | |
521(231) | N | T | N | |
600(310) | R | K | R | |
628(338) | I | V | I | |
655(365) | S | A | S | |
700(410) | A | T | A | |
773(483) | L | L | F | |
NS1 | ||||
837(46) | I | I | V | |
879(88) | I | V | I | |
893(102) | R | K | R | |
926(135) | I | V | I | |
937(146) | Q | Q | R | |
961(170) | R | K | R | |
997(206) | F | L | L | 5(2):12(2):9(0) |
1027(236) | V | I | V | |
1036(245) | I | V | I | |
1055(264) | S | N | S | |
1081(290) | S | S | N | |
1089(298) | T | T | I | |
1118(327) | N | S | N | |
NS2A | ||||
1255(112) | A | V | V | |
1262(119) | Y | H | Y | |
1272(129) | M | I | I | |
1311(168) | C | R | C | 5(0):5(2):6(2) |
1326(183) | I | I | V | |
1330(187) | I | I | M | |
1355(212) | F | L | F | |
1366(223) | V | I | I | |
NS2B | ||||
1400(26) | I | I | M | |
1438(64) | G | S | S | 2(1):2(0):2(1) |
1477(103) | A | V | A | |
1520(15) | R | K | K | |
1615(110) | Q | R | Q | |
1680(174) | V | I | V | |
1754(249) | A | P | A | |
1809(303) | R | K | R | |
1836(331) | A | S | A | 3(0):12(6):11(6) |
1861(356) | I | T | I | |
1887(382) | K | K | R | |
1889(383) | I | V | I | |
1912(406) | V | I | V | |
1970(465) | N | N | S | |
1991(486) | C | F | C | |
2115(610) | S | A | S | |
NS4A | ||||
2129(5) | F | L | F | |
2179(55) | A | A | T | |
2209(85) | V | A | V | |
2213(89) | A | V | A | 2(2):5(1):5(1) |
2265(141) | L | M | L | |
2269(145) | G | S | S | |
NS4B | ||||
2288(15) | G | S | G | |
2296(23) | T | V | I | |
2302(29) | I | M | I | |
2324(50) | V | V | F | |
2334(60) | T | T | M | 7(4):11(5):7(3) |
2368(94) | A | A | S | |
2387(114) | S | A | S | |
2389(116) | T | T | A | |
2449(176) | V | I | V | |
2450(177) | M | M | I | |
2459(186) | L | V | L | |
2518(245) | V | I | I | |
NS5 | ||||
2553(25) | I | T | I | |
2561(33) | T | I | T | |
2575(47) | R | G | R | |
2577(48) | I | V | V | |
2629(101) | R | R | K | |
2690(162) | L | I | L | |
2705(177) | K | R | K | 7(3):15(7):12(8) |
2711(183) | V | V | I | |
2775(247) | K | R | K | |
2840(311) | E | D | E | |
3059(531) | R | K | R | |
3088(560) | D | D | N | |
3181(653) | S | F | F | |
3247(719) | T | T | I | |
3259(731) | T | V | T | |
3405(877) | S | A | S | |
3427(899) | L | L | F | |
Total changes | 42(18):89(38):77(34 |
*WNV, West Nile virus; NY, New York; NSW, New South Wales; C, core; NS, nonstructural; PrM, precursor membrane; E, envelope.
†No. aa differences (nonconservative changes in parentheses) for WNVKUN vs. WNVNSW2011:WNVNY99 vs. WNVNSW2011:WNVKUN vs. WNVNY99.
1These authors contributed equally to the major technical aspects of this research.
2These authors served as joint senior authors.