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Volume 18, Number 5—May 2012


Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011

Melinda J. Frost1, Jing Zhang1, Judith H. Edmonds1, Natalie A. Prow1, Xingnian Gu, Rodney Davis, Christine Hornitzky, Kathleen E. Arzey, Deborah Finlaison, Paul Hick, Andrew Read, Jody Hobson-Peters, Fiona J. May, Stephen L. Doggett, John Haniotis, Richard C. Russell, Roy A. Hall2, Alexander A. Khromykh2, and Peter D. Kirkland2Comments to Author 
Author affiliations: Elizabeth Macarthur Agriculture Institute, Menangle, New South Wales, Australia (M.J. Frost, J. Zhang, X. Gu, R. Davis, C. Hornitzky, K.E. Arzey, D. Finlaison, P. Hick, A. Read, P.D. Kirkland); The University of Queensland, St Lucia, Queensland, Australia (J.H. Edmonds, N.A Prow, J. Hobson-Peters, F.J. May, R.A. Hall, A. A. Khromykh); University of Sydney and Westmead Hospital, Westmead, New South Wales, Australia (S.L. Doggett, J. Haniotis, R.C. Russell)

Main Article

Table 5

Virulence of 3 WNVs in 4-week-old mice after intraperitoneal injection, Australia, 2011*

Virus and dose, PFU No. mice/no. died Average survival time, d LD50
100 10/10 8.3  
10 10/10 8.2 0.7 PFU
1 5/10 8.6  
0.1 2/10 10  
1,000 0/10 21 >1,000 PFU
1,000 7/10 10.7  
100 2/10 11 240 PFU
10 3/10 10.3  

*WNV, West Nile virus; LD50, dose at which 50% of the mice died; NY, New York; KUN, Kunjin; NSW, New South Wales.

Main Article

1These authors contributed equally to the major technical aspects of this research.

2These authors served as joint senior authors.