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Volume 18, Number 6—June 2012
CME ACTIVITY - Synopsis

Iatrogenic Creutzfeldt-Jakob Disease, Final Assessment

Paul BrownComments to Author , Jean-Philippe Brandel, Takeshi Sato, Yosikazu Nakamura, Jan MacKenzie, Robert G. Will, Anna Ladogana, Maurizio Pocchiari, Ellen W. Leschek, and Lawrence B. Schonberger
Author affiliations: Centre à l’Energie Atomique, Fontenay-aux-Roses, France (P. Brown); Institut National de la Santé et de la Recherche Médicale, Paris, France (J.-P. Brandel); Nanohana Clinic, Tokyo, Japan (T. Sato); Jichi Medical University, Yakushiji, Japan (Y. Nakamura); Western General Hospital, Edinburgh, Scotland, UK (J. MacKenzie, R.G. Will); Istituto Superiore de Sanità, Rome, Italy (A. Ladogana, M. Pocchiari); National Institutes of Health, Bethesda, Maryland, USA (E.W. Leschek); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (L.B. Schonberger)

Main Article

Table 2

Incubation periods and clinical presentations of iatrogenic Creutzfeldt-Jakob disease, according to source of infection*

Source of Infection No. cases Mean incubation period, y (range) Clinical signs†
Dura mater graft 228 12 (1.3–30) Cerebellar, visual, dementia
Neurosurgical instruments 4 1.4 (1–2.3) Visual, dementia, cerebellar
Stereotactic EEG needles 2 1.3, 1.7 Dementia, cerebellar
Corneal transplant 2 1.5, 27 Dementia, cerebellar
Growth hormone 226 17 (5–42)‡ Cerebellar
Gonadotropin 4 13.5 (12–16) Cerebellar
Packed red blood cells§ 3 6.5, 7.8, 8.3 Psychiatric, sensory, dementia, cerebellar

*EEG, electroencephalogram.
†In order of decreasing frequency.
‡Averages and ranges were 13 (5–24) y in France; 20 (7–39) y in the United Kingdom; and 22 (10–42) y in the United States.
§An additional asymptomatic but infected red-cell recipient died of an unrelated illness; another asymptomatic infected hemophilia patient who had been exposed to potentially contaminated factor VIII also died of an unrelated illness (neither is included in the table).

Main Article

Page created: May 17, 2012
Page updated: May 17, 2012
Page reviewed: May 17, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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