Volume 18, Number 7—July 2012
Dispatch
Dobrava Hantavirus Infection Complicated by Panhypopituitarism, Istanbul, Turkey, 2010
Nevin Sarıgüzel1
, Jörg Hofmann1, Alper Tunga Canpolat, Ali Türk, Jakob Ettinger, Deniz Atmaca, Işın Akyar, Serap Yücel, Ender Arıkan, Yavuz Uyar, Dilek Y. Çağlayık, Ayşe Sesin Kocagöz, Ayşin Kaya, and Detlev H. Kruger
, Jörg Hofmann1, Alper Tunga Canpolat, Ali Türk, Jakob Ettinger, Deniz Atmaca, Işın Akyar, Serap Yücel, Ender Arıkan, Yavuz Uyar, Dilek Y. Çağlayık, Ayşe Sesin Kocagöz, Ayşin Kaya, and Detlev H. Kruger
Table 1
Hematologic and biochemical parameters of DOBV hantavirus patient, Istanbul, Turkey, 2010*
| Laboratory test (reference range) | Day of hospitalization |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 | 1 | 2 | 3 | 4 | 5 | 15 | 20 | 71 | |
| Leukocytes, × 103 cells/mm3 (4.5–11) | 5.8 | 9.9 | 15.2 | 27.6 | 24 | 25 | 11.3 | 4.7 | 7.7 |
| Hemoglobin, g/dL (11.7–15.5) | 16 | 16.5 | 18 | 16 | 13.3 | 10.7 | 8.2 | 8.9 | 12.1 |
| Hematocrit, % (36–46) | 46.7 | 48 | 51.8 | 45.2 | 38.3 | 31.2 | 24.6 | 27 | 36.6 |
| Platelets, × 103/mm3 (130–450) | 63 | 19 | 20 | 13 | 37 | 55 | 180 | 171 | 254 |
| ALT, U/L (10–40) | 95 | 92 | 58 | 67 | 157 | 539 | 79 | 60 | 20 |
| AST, U/L (15–40) | 99 | 117 | –† | – | 497 | 2234 | 106 | 84 | 25 |
| BUN, mg/dL (4.67–23.3) | – | 18 | 23 | 30 | 41 | 41 | 129 | 74 | 19 |
| Creatinine, mg/dL (0.7–1.2) | – | 0.8 | 1.8 | 2.4 | 3.3 | 3.1 | 7.3 | 6.4 | 1.92 |
| aPTT, s (4–40) | – | 39 | 43 | – | 32.5 | 37.1 | 30.8 | – | – |
| PT, s (10–14 s) | – | 13.3 | 11.6 | – | 17.5 | 20 | 14.1 | – | – |
| Ferritin, ng/mL (15–200) | – | 5,304 | – | – | 14,036 | – | – | – | – |
| TSH, U/mL (0.4–4.2) | – | 1.71 | – | – | – | – | – | 2.83 | 0.92 |
| Free thyroxin, pmol/L (10.3–23.2) | – | – | – | – | – | – | – | 0.18 | 14.3 |
| Cortisol, μg/dL (6.2–19.4) | – | – | – | – | – | 45.0 | – | 0.98 | 4.7 |
| ACTH, pg/mL (0–46) | – | – | – | – | – | 3.02 | – | 6.80 | – |
| ADH, pg/mL (0.8–4.5) | – | – | – | – | – | – | – | 2.2 | – |
| Total testosterone, ng/mL (2.8–8.0) | – | – | – | – | – | – | – | <0.025 | 1.9 |
| LH, mIU/mL (1.7–8.6) | – | – | – | – | – | – | – | <0.1 | – |
| FSH, mIU/mL (1.5–12.4) | – | – | – | – | – | – | – | 0.66 | – |
| Prolactin, mIU/mL (4.6–21.4) | – | – | – | – | – | – | – | 10.05 | – |
| Somatomedin-C/IGF-1, ng/mL (115–307) | – | – | – | – | – | – | – | <25 | – |
*DOBV, Dobrava-Belgrade virus; ALT, alanine transaminase; AST, aspartate aminotransferase; BUN, blood urea nitrogen; aPTT, activated partial thromboplastin time; PT, prothrombin time; TSH, thyroid stimulating hormone; ACTH, adrenocorticotropic hormone; ADH, antidiuretic hormone; LH, luteinizing hormone; FSH, follicle-stimulating hormone; IGF, insulin-like growth factor.
†Test not performed.
1These authors contributed equally to this article.
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