Volume 18, Number 8—August 2012
CME ACTIVITY - Synopsis
Vaccination of Health Care Workers to Protect Patients at Increased Risk for Acute Respiratory Disease
|Outcome measure and study||Study design||Method of assessment||Measure of effect in patient population||Effect estimate (95% CI)|
|Carman et al. (24)||Cluster RCT||Nasal and oropharyngeal swabs (tissue culture/RT-PCR)||Difference in proportions||Routine surveillance, p = 0.42; opportunistic sampling, p = 0.54|
|Thomas et al (19)||Pooled data†||OR, adjusted for clustering||0.87 (0.38–1.99), p = 0.74|
|Weinstock et al. (32)||Ecologic||Clinical definition plus positive shell viral assay, enzyme immunoassay, or tissue culture||Difference in proportions (before to after implementation)||72.1% decrease, p<0.01|
|Engels et al. (31)||Ecologic||Nasopharyngeal aspirate culture||Difference in proportions (before to after implementation)||p<0.001, all children); p = 0.05, children with underlying disease; p<0.05, children <24 mos|
|Laboratory-diagnosed outbreaks of ILI, Monto et al. (36)||Cohort with case–control analysis||Laboratory confirmation of cases by using rapid antigen detection testing, viral cell culture, or RT-PCR||Difference in proportions||Median staff vaccination coverage in homes with outbreaks = 42% vs. 24% in homes without outbreaks, p>0.05|
*HCW, health care worker; RCT, randomized controlled trial; RT-PCR, reverse transcription PCR; OR, odds ratio. Boldface indicates statistical significance. Shading indicates pooled data.
†Pooled by using data from Potter and Carman but no estimate of effect reported by Potter et al.
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