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Volume 18, Number 8—August 2012
Peer Reviewed Report Available Online Only

Infectious Disease Transmission during Organ and Tissue Transplantation

Melissa A. GreenwaldComments to Author , Matthew J. Kuehnert, and Jay A. Fishman
Author affiliations: Food and Drug Administration, Rockville, Maryland, USA (M.A. Greenwald); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (M.J. Kuehnert); Massachusetts General Hospital, Boston, Massachusetts, USA (J.A. Fishman); and Harvard Medical School, Boston (J.A. Fishman)

Main Article

Table 3

Key research factors and needs for organ and tissue transplant–associated infections

Factor Need
Denominator data Tissue transplantation: number and type of allografts transplanted
Discard rate: number of donors rejected for organ and tissue transplantation because of identified donor risk
Transmissibility data Preclinical: animal studies, studies of unused organs, or tissues from infected donors
Clinical studies: outcomes from increased risk organ donors
Risk mitigation strategies Processing: tissue processing, pump perfusion of organs
Effects of antimicrobial agents: in organ donors, in organ or tissue recipients
Donor questionnaire Effectiveness of questions for obtaining accurate answers and for identifying donors with higher likelihood of having a positive test result
Research infrastructure Organized network: to collect, share, and analyze data in organ and tissue transplantation
Harmonization: product names, label information, data collection methods, data sharing mechanisms
Risk assessment Use of data: model risks, further refine research needs
Quality improvement: evaluate effectiveness of changes, refine models for use with emerging diseases

Main Article

Page created: July 11, 2012
Page updated: July 11, 2012
Page reviewed: July 11, 2012
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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