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Volume 20, Number 1—January 2014

Multisite Validation of Cryptococcal Antigen Lateral Flow Assay and Quantification by Laser Thermal Contrast

David R. BoulwareComments to Author , Melissa A. Rolfes, Radha Rajasingham, Maximilian von Hohenberg, Zhenpeng Qin, Kabanda Taseera, Charlotte Schutz, Richard Kwizera, Elissa K. Butler, Graeme Meintjes, Conrad Muzoora, John C. Bischof, and David B. Meya
Author affiliations: University of Minnesota, Minneapolis, Minnesota, USA (D.R. Boulware, M.A. Rolfes, R. Rajasingham, M. von Hohenberg, Z. Qin, E.K. Butler, J.C. Bischof, D.B. Meya); Makerere University, Kampala, Uganda (R. Rajasingham, R.K. Kwizera, D.B. Meya); Mbarara University of Science and Technology, Mbarara, Uganda (K. Taseera, C. Muzoora); G.F. Jooste Hospital, Cape Town, South Africa (C. Schutz, G. Meintjes); University of Cape Town, Cape Town (C. Schutz, G. Meintjes)

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Table 3

Characteristics of CSF specimens with false-negative results by cryptococcal antigen lateral flow immunochromatographic assay, 2006–2009 cohort, Uganda and South Africa*

CSF culture, CFU/mL India ink microscopy CSF latex agglutination test dilution† CSF CRAG LFA
100 1:2 Meridian; 1:1 Immy –‡
0 + 1:2 Meridian; 1:1 Immy –‡
0 + 1:2 Meridian; 1:1 Immy –‡

*CSF, cerebrospinal fluid; CRAG, cryptococcal antigen; LFA, lateral flow immunochromatographic assay; CFU, colony-forming units of Cryptococcus neoformans; –, negative; +, positive.
†Meridian, Cincinnati, OH, USA; Immy, Inc., Norman, OK, USA.
‡Retrospectively performed with cryopreserved specimens.

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Page created: January 03, 2014
Page updated: January 03, 2014
Page reviewed: January 03, 2014
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