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Volume 20, Number 2—February 2014
Research

Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children

Giske Biesbroek, Xinhui Wang1, Bart J.F. Keijser1, Rene M.J. Eijkemans, Krzysztof Trzciński, Nynke Y. Rots, Reinier H. Veenhoven2, Elisabeth A.M. Sanders, and Debby BogaertComments to Author 
Author affiliations: University Medical Center Utrecht, Utrecht, the Netherlands (G. Biesbroek, X. Wang, K. Trzciński, E.A.M. Sanders. D. Bogaert); TNO, Zeist, the Netherlands (G. Biesbroek, B.J.F. Keijser); Julius Center for Health Sciences and Primary Care, Utrecht (R.M.J. Eijkemans); Netherlands Vaccine Institute, Bilthoven, the Netherlands (N.Y. Rots); Spaarne Hospital, Hoofddorp, the Netherlands (R.H. Veenhoven)

Main Article

Figure 1

Weighted UniFrac analyses (23) of nasopharyngeal samples of children at 12 and 24 months of age vaccinated with 7-valent pneumococcal conjugate vaccine. Clustering of samples was based on evolutionary (phylogenetic) relatedness by using Weighted UniFrac analyses. Clustering is shown in a circle dendrogram. Each branch represents a sample and each adjacent histogram represents the relative abundance of the top 5 operational taxonomic units (OTUs) found in that sample. Differences in length of bra

Figure 1. Weighted UniFrac analyses (23) of nasopharyngeal samples of children at 12 and 24 months of age vaccinated with 7-valent pneumococcal conjugate vaccineClustering of samples was based on evolutionary (phylogenetic) relatedness by using Weighted UniFrac analysesClustering is shown in a circle dendrogramEach branch represents a sample and each adjacent histogram represents the relative abundance of the top 5 operational taxonomic units (OTUs) found in that sampleDifferences in length of branches among samples reflect their distance (i.e., dissimilarity) to each otherBranches of reference samples were collapsed and are represented by black trianglesSamples are mostly dominated by Moraxella, Streptococcus, and Haemophilus spp., or the combination of Dolosigranulum and Corynebacterium spp., which highly affects sample clustering by Weighted UniFracBranches are colored according to age of sampled children (purple = 12 months, green = 24 months)No clear clustering of samples by age was observed.

Main Article

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Main Article

1These authors contributed equally to this article.

2Deceased.

Page created: January 17, 2014
Page updated: January 17, 2014
Page reviewed: January 17, 2014
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