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Volume 20, Number 2—February 2014
Research

Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children

Giske Biesbroek, Xinhui Wang1, Bart J.F. Keijser1, Rene M.J. Eijkemans, Krzysztof Trzciński, Nynke Y. Rots, Reinier H. Veenhoven2, Elisabeth A.M. Sanders, and Debby BogaertComments to Author 
Author affiliations: University Medical Center Utrecht, Utrecht, the Netherlands (G. Biesbroek, X. Wang, K. Trzciński, E.A.M. Sanders. D. Bogaert); TNO, Zeist, the Netherlands (G. Biesbroek, B.J.F. Keijser); Julius Center for Health Sciences and Primary Care, Utrecht (R.M.J. Eijkemans); Netherlands Vaccine Institute, Bilthoven, the Netherlands (N.Y. Rots); Spaarne Hospital, Hoofddorp, the Netherlands (R.H. Veenhoven)

Main Article

Figure 2

Nonmetric multidimensional scaling (nMDS) of microbiota profiles of children vaccinated with 7-valent pneumococcal conjugate vaccine and control children at 12 and 24 months of age. Microbiota profiles were compared between groups by using nMDS to find dissimilarities between samples and locate samples in a 2-dimensional space. Each circle represents the microbiota profile of a sample. Boxes indicate geometric means of both groups in which the length of the line between the sample (circle) and t

Figure 2. Nonmetric multidimensional scaling (nMDS) of microbiota profiles of children vaccinated with 7-valent pneumococcal conjugate vaccine and control children at 12 and 24 months of ageMicrobiota profiles were compared between groups by using nMDS to find dissimilarities between samples and locate samples in a 2-dimensional spaceEach circle represents the microbiota profile of a sampleBoxes indicate geometric means of both groups in which the length of the line between the sample (circle) and the geometric mean (box) indicates the distance of that sample from the geometric meanLonger lines indicate higher distances of samples (i.e., higher variability between sample compositions)A) nMDS plots of vaccinated children (blue lines) and controls (red lines) at 12 months of ageThe geometric mean of microbiota profiles differed significantly (p = 0.01, by F-test) between vaccinated children and controlsB) nMDS plots of vaccinated children (blue lines) and controls (red lines) at 24 months of age, showing no differences in geometric means of microbiota profiles between the 2 groups.

Main Article

1These authors contributed equally to this article.

2Deceased.

Page created: January 17, 2014
Page updated: January 17, 2014
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