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Volume 20, Number 2—February 2014
Research

Seven-Valent Pneumococcal Conjugate Vaccine and Nasopharyngeal Microbiota in Healthy Children

Giske Biesbroek, Xinhui Wang1, Bart J.F. Keijser1, Rene M.J. Eijkemans, Krzysztof Trzciński, Nynke Y. Rots, Reinier H. Veenhoven2, Elisabeth A.M. Sanders, and Debby BogaertComments to Author 
Author affiliations: University Medical Center Utrecht, Utrecht, the Netherlands (G. Biesbroek, X. Wang, K. Trzciński, E.A.M. Sanders. D. Bogaert); TNO, Zeist, the Netherlands (G. Biesbroek, B.J.F. Keijser); Julius Center for Health Sciences and Primary Care, Utrecht (R.M.J. Eijkemans); Netherlands Vaccine Institute, Bilthoven, the Netherlands (N.Y. Rots); Spaarne Hospital, Hoofddorp, the Netherlands (R.H. Veenhoven)

Main Article

Figure 3

Mean absolute abundances of operational taxonomic units (OTUs) in children vaccinated with 7-valent pneumococcal conjugate vaccine and control children at 12 and 24 months of age. The 25 most abundant OTUs are represented by different colors. *OTUs that showed significantly higher abundance in vaccinated children than in controls (p<0.0003). Although not significant, an apparent higher average absolute abundance was observed for Haemophilus and Staphylococcus spp. in vaccinated children than

Figure 3. Mean absolute abundances of operational taxonomic units (OTUs) in children vaccinated with 7-valent pneumococcal conjugate vaccine and control children at 12 and 24 months of ageThe 25 most abundant OTUs are represented by different colors*OTUs that showed significantly higher abundance in vaccinated children than in controls (p<0.0003)Although not significant, an apparent higher average absolute abundance was observed for Haemophilus and Staphylococcus sppin vaccinated children than in control children at 12 months of age†OTUs that showed a trend toward higher abundance in vaccinated children than in controls (0.0003<p<0.05).

Main Article

1These authors contributed equally to this article.

2Deceased.

Page created: January 17, 2014
Page updated: January 17, 2014
Page reviewed: January 17, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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