Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 20, Number 3—March 2014
Dispatch

Nontoxigenic tox-bearing Corynebacterium ulcerans Infection among Game Animals, Germany

Tobias EisenbergComments to Author , Peter Kutzer, Martin Peters, Andreas Sing, Matthias Contzen, and Jörg Rau
Author affiliations: Landesbetrieb Hessisches Landeslabor, Gießen, Germany (T. Eisenberg); Landeslabor Berlin-Brandenburg, Frankfurt (Oder), Germany (P. Kutzer); Chemisches und Veterinäruntersuchungsamt Westfalen, Standort Arnsberg, Germany (M. Peters); Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit, Oberschleißheim, Germany (A. Sing); Chemisches und Veterinäruntersuchungsamt Stuttgart, Fellbach, Germany (M. Contzen, J. Rau)

Main Article

Table 1

Origin of nontoxigenic tox-bearing Corynebacterium ulcerans field strains among game animals and gross pathology results from necropsies, Germany

Case no. Isolate ID Year of isolation State/district of origin Host species Circumstances of death; gross pathology results Source
1 Bu125/97 1997 North Rhine-Westphalia/ Siegen-Wittgenstein Wild boar Meat-inspection; lamellar lymph node abscess This study
2 CVUAS 4292 2009 Baden Wuerttemberg/ Enz Wild boar Found dead; multiple lamellar lymph node abscesses; 
multiple hypertrophic lymphangitis (5)
3 CVUAS 5160 2009 Baden Wuerttemberg/ Main-Tauber Wild boar Shot; superficial cervical lymph nodes greatly enlarged; abscess of Ln. mandibularis (5)
4 CVUAS 6455 2010 Baden Wuerttemberg/ Aalen Roe deer Moribund; grapefruit-sized abscess of or near left Ln. cervicalis superficialis (8)
5 10–7-D-00025 2010 Hesse/ Lahn-Dill Wild boar Shot; female; lamellar thoracic plum-sized lymph node abscess This study
6 11USF28 2011 Brandenburg/ Havelland Wild boar Found dead; male, ≈2 y old; subcutaneous abscess This study
7 11USF53 2011 Brandenburg/ Havelland Wild boar Shot; female, ≈3 y old; lung abscess This study
8 11USF78 2011 Brandenburg/ Havelland Wild boar Shot; female, ≈1 y old; subcutaneous abscess This study
9 11USF79 2011 Brandenburg/ Havelland Wild boar Shot; male, ≈1 y old; subcutaneous abscess This study
10 121017479 2012 Hesse/ Marburg Wild boar Shot; some milium- to pea-sized solid grayish abscesses with dystrophic central calcification in diaphragmatic peritoneum This study
11 S1627/5/12 2012 North Rhine-Westphalia/ Siegen-Wittgenstein Wild boar Shot; 1 y old; multiple lamellar abscesses in cervical and pulmonal lymph nodes This study
12 S28/3/13 2013 Hesse/ Bad Hersfeld Wild boar Shot; 2 y old; isolate from teat abscess; multiple lamellar abscesses in cervical lymph nodes This study
13 131000349 2013 Hesse/ Odenwald Wild boar Found dead; female, ≈1 y old; some cherry-sized subcutaneous lymph node abscesses This study

Main Article

References
  1. Pascual  C, Lawson  PA, Farrow  JA, Gimenez  MN, Collins  MD. Phylogenetic analysis of the genus Corynebacterium based on 16S rRNA gene sequences. Int J Syst Bacteriol. 1995;45:7248. DOIPubMedGoogle Scholar
  2. Wong  TP, Groman  N. Production of diphtheria toxin by selected isolates of Corynebacterium ulcerans and Corynebacterium pseudotuberculosis. Infect Immun. 1984;43:11146 .PubMedGoogle Scholar
  3. Funke  G, von Graevenitz  A, Clarridge  JE III, Bernard  KA. Clinical microbiology of coryneform bacteria. Clin Microbiol Rev. 1997;10:12559 .PubMedGoogle Scholar
  4. Wagner  KS, White  JM, Crowcroft  NS, De Martin  S, Mann  G, Efstratiou  A. Diphtheria in the United Kingdom, 1986–2008: the increasing role of Corynebacterium ulcerans. Epidemiol Infect. 2010;138:151930 . DOIPubMedGoogle Scholar
  5. Contzen  M, Sting  R, Blazey  B, Rau  J. Corynebacterium ulcerans from diseased wild boars. Zoonoses Public Health. 2011;58:47988 . DOIPubMedGoogle Scholar
  6. Engler  KH, Glushkevich  T, Mazurova  IK, George  RC, Efstratiou  A. A modified Elek test for detection of toxigenic corynebacteria in the diagnostic laboratory. J Clin Microbiol. 1997;35:4958 .PubMedGoogle Scholar
  7. Sing  A, Hogardt  M, Bierschenk  S, Heesemann  J. Detection of differences in the nucleotide and amino acid sequences of diphtheria toxin from Corynebacterium diphtheriae and Corynebacterium ulcerans causing extrapharyngeal infections. J Clin Microbiol. 2003;41:484851 . DOIPubMedGoogle Scholar
  8. Rau  J, Blazey  B, Contzen  M, Sting  R. Corynebacterium ulcerans infection in roe deer (Capreolus capreolus). Berl Munch Tierarztl Wochenschr. 2012;125:15962 .PubMedGoogle Scholar
  9. Sing  A, Berger  A, Schneider-Brachert  W, Holzmann  T, Reischl  U. Rapid detection and molecular differentiation of toxigenic Corynebacterium diphtheriae and Corynebacterium ulcerans strains by LightCycler PCR. J Clin Microbiol. 2011;49:24859. DOIPubMedGoogle Scholar
  10. Foster  G, Patterson  T, Howie  F, Simpson  V, Davison  N, Efstratiou  A, Corynebacterium ulcerans in free-ranging otters. Vet Rec. 2002;150:524 .PubMedGoogle Scholar
  11. Olson  ME, Goemans  I, Bolingbroke  D, Lundberg  S. Gangrenous dermatitis caused by Corynebacterium ulcerans in Richardson ground squirrels. J Am Vet Med Assoc. 1988;193:3678 .PubMedGoogle Scholar
  12. Khamis  A, Raoult  D, La Scola  B. Comparison between rpoB and 16S rRNA gene sequencing for molecular identification of 168 clinical isolates of Corynebacterium. J Clin Microbiol. 2005;43:19346. DOIPubMedGoogle Scholar
  13. Schuhegger  R, Schoerner  C, Dlugaiczyk  J, Lichtenfeld  I, Trouillier  A, Zeller-Peronnet  V, Pigs as source for toxigenic Corynebacterium ulcerans. Emerg Infect Dis. 2009;15:13145. DOIPubMedGoogle Scholar
  14. Berger  A, Boschert  V, Konrad  R, Schmidt-Wieland  T, Hörmansdorfer  S, Eddicks  M, Two cases of cutaneous diphtheria associated with occupational pig contact in Germany. Zoonoses Public Health. 2013;60:53942 . DOIPubMedGoogle Scholar

Main Article

Reference has only first page number. Please provide the last page number if article is longer than one page. (in reference 10 "Foster, Patterson, Howie, Simpson, Davison, Efstratiou, et al., 2002").

Page created: February 19, 2014
Page updated: February 19, 2014
Page reviewed: February 19, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external