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Volume 20, Number 3—March 2014

Use of Drug-Susceptibility Testing for Management of Drug-Resistant Tuberculosis, Thailand, 2004–2008

Eugene Lam, Sriprapa Nateniyom, Sara Whitehead, Amornrat Anuwatnonthakate, Patama Monkongdee, Apiratee Kanphukiew, Jiraphan Inyaphong, Wanlaya Sitti, Navarat Chiengsorn, Saiyud Moolphate, Suporn Kavinum, Narin Suriyon, Pranom Limsomboon, Junya Danyutapolchai, Chalinthorn Sinthuwattanawibool, and Laura Jean PodewilsComments to Author 
Author affiliations: US Centers for Disease Control and Prevention (US CDC), Atlanta, Georgia, USA (E. Lam, S. Whitehead, L.J. Podewils); Thailand Ministry of Public Health (MOPH), Nonthaburi, Thailand (S. Nateniyom); Thailand MOPH–US CDC, Nonthaburi (S. Whitehead, A. Anuwatnonthakate, P. Monkongdee, A. Kanphukiew, J. Danyutapolchai, C. Sinthuwattanawibool); Office of Disease Prevention and Control 7, Ubon-ratchathani, Thailand (J. Inyaphong, W. Sitti); Bangkok Metropolitan Health Administration, Bangkok Thailand (N. Chiengsorn); Research Institute of Tuberculosis (RIT-Japan), Tokyo, Japan (S. Moolphate); Tak Provincial Public Health Office, Tak, Thailand (S. Kavinum); Chiang Rai Provincial Public Health Office, Chiang Rai, Thailand (N. Suriyon); Phuket Provincial Public Health Office, Phuket, Thailand (P. Limsomboon)

Main Article

Table 4

Association between baseline sociodemographic and clinical characteristics and prescription of an inappropriate MDR TB treatment regimen for 172 MDR TB patients 2004–2008*

Characteristic Univariate OR (95% CI) p value Multivariate OR (95% CI)† p value
Age, y
<45 Reference
>45 0.54 (0.2–1.2) 0.13
Male Reference
Female 0.74 (0.3–1.8) 0.49
Marital Status
Married Reference
Single/divorced/widowed 0.44 (0.2–1.0) 0.06
Thai Reference
Non-Thai 1.0 (0.4–3.0) 0.95
Case status
New Reference Reference
Retreatment 2.4 (1.0–5.9) 0.05 2.6 (1.0–6.3) 0.04
Transfer in/other 2.8 (0.9–8.7) 0.08 2.9 (0.9–9.3) 0.07
Site of TB
Pulmonary Reference
Extrapulmonary or both 0.41 (0.1–3.3) 0.40
Cough >2 wk
No Reference
Yes 1.6 (0.6–4.6) 0.35
Smear status
Negative Reference
Positive 6.5 (0.8–50.2) 0.07
Cavitation seen on chest x-ray
No Reference
Yes 0.40 (0.1–1.4) 0.16
HIV status
Negative Reference
Positive 0.38 (0.1–1.2) 0.09
Resistance pattern
INH + RIF Reference
INH + RIF + EMB or INH + RIF + STR 0.80 (0.3–2.1) 0.65
INH + RIF + EMB + STR 2.1 (0.8–5.6) 0.13
Delay from sputum collection to firs post-DST visit, d
35–74 Reference
75–112 1.3 (04–4.6) 0.70
113–155 1.8 (0.5–6.2) 0.38
>155 1.0 (0.3–3.8) 0.97

*The patients were from 5 Thailand provinces participating in the Thailand Active TB Surveillance Network. OR, odds ratio; MDR, multidrug resistant; TB, tuberculosis; INH, isoniazid; RIF, rifampin; EMB, ethambutol; STR, streptomycin; DST, drug-susceptibility testing.
†Adjusted for age as a continuous variable.

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Page created: February 25, 2014
Page updated: February 25, 2014
Page reviewed: February 25, 2014
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