Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 20, Number 3—March 2014
Research

Minimal Diversity of Drug-Resistant Mycobacterium tuberculosis Strains, South Africa1

Neel R. GandhiComments to Author , James C.M. Brust, Prashini Moodley, Darren Weissman, Moonseong Heo, Yuming Ning, Anthony P. Moll, Gerald H. Friedland, A. Willem Sturm, and N. Sarita Shah
Author affiliations: Albert Einstein College of Medicine, Bronx, New York, USA (N.R. Gandhi, J.C.M. Brust, D. Weissman, M. Heo, Y. Ning, N.S. Shah); Rollins School of Public Health, Emory University, Atlanta, Georgia, USA (N.R. Gandhi); Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa (P. Moodley, A.W. Sturm); Philanjalo, Tugela Ferry, South Africa (A.P. Moll); Church of Scotland Hospital, Tugela Ferry (A.P. Moll); Yale University School of Medicine, New Haven, Connecticut, USA (G.H. Friedland)

Main Article

Table 2

Spoligotype patterns of Mycobacterium tuberculosis isolates from patients in Tugela Ferry, KwaZulu-Natal Province, South Africa, 2005–2006*†‡

Lineage
 Shared type
 International family
 Octal code
 DS TB strains, n = 115
 MDR TB strains, n = 79
 XDR TB strains, n = 92
Beijing
 1
 Beijing
 000000000003771
 31
 2
 0
LAM 4 LAM3/S 000000007760771 2 0 0
33 LAM3 776177607760771 12 0 1
42 LAM9 777777607760771 1 1 1
60 LAM4 777777607760731 7 21 82
211 LAM3 776137607760771 2 0 0
811 LAM4 777777604060731 1 0 0
1321 LAM1-LAM4 677777607760731 1 0 0
1624 LAM3-LAM6 776177607560771 1 0 0
1750
 LAM4
 777767607760731
 0
 1
 0
S family 34 S 776377777760771 4 27 0
466 S 776377377760771 1 0 0
831
 S
 776367777760771
 1
 2
 0
T family 37 T3 777737777760771 0 5 0
39 T4-CEU1 777777347760471 1 0 0
53 T1 777777777760771 10 6 4
118 T2 777767777760771 1 0 0
136 T1 777603405760471 0 0 1
205 T1 737777777760771 2 0 0
244 T1 777777777760601 2 1 0
334 T1 577777777760771 1 0 0
358 T1 717777777760771 1 0 0
719 T1 776177407760771 3 0 0
766 T1 777761007760771 0 2 0
879 T1 777767777760671 1 0 0
926 T1 773777777760771 0 5 0
1166 T1 777377777760771 0 1 1
1547
 T3
 777727777760771
 0
 1
 0
X family 200 X3 700076777760700 1 0 0
336 X1 777776777760731 0 0 1
1751
 X3
 700066777760771
 1
 0
 0
Haarlem 47 H1 777777774020771 2 0 0
50 H3 777777777720771 2 0 0
62 H1-variant1 777777774020731 1 1 0
75 H3 777767777720771 1 0 0
294
 H3
 577777777720771
 1
 0
 0
Other 21 CAS1-Kili 703377400001771 3 0 0
26 CAS1-Delhi 703777740003771 3 0 0
71 EAI-undefined 776337777760771 1 0 0
172 U 777777777740771 1 0 0
374 U 777777776000771 1 0 0
583 MANU2 777737777763771 1 1 0
806 EAI1-SOM 757777777413731 1 0 0
1092
 CAS
 702777740003771
 3
 0
 0
*DS TB, drug-susceptible tuberculosis; MDR TB, multidrug-resistant TB; XDR TB, extensively drug-resistant TB. Boldface indicates the most common strain for each resistance group.
†Does not include 11 isolates with unknown drug-susceptibility test results.
‡See online Technical Appendix (wwwnc.cdc.gov/EID/article/20/3/13-1083-Techapp1.pdf) for all spoligotype patterns in binary format.

Main Article

1Preliminary results from this study were presented at the American Thoracic Society International Conference, May 15–20, 2009, San Diego, California, USA.

Page created: February 19, 2014
Page updated: February 19, 2014
Page reviewed: February 19, 2014
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external