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Volume 20, Number 3—March 2014


Possible Role of Songbirds and Parakeets in Transmission of Influenza A(H7N9) Virus to Humans

Jeremy C. Jones, Stephanie Sonnberg, Zeynep A. Koçer, Karthik Shanmuganatham, Patrick Seiler, Yuelong Shu, Huachen Zhu, Yi Guan, Malik Peiris, Richard J. Webby, and Robert G. WebsterComments to Author 
Author affiliations: St. Jude Children’s Research Hospital, Memphis, Tennessee, USA (J.C. Jones, S. Sonnberg, Z.A. Kocer, K. Shanmuganatham, P. Seiler, R.J. Webby, R.G. Webster); Chinese Center for Disease Control and Prevention, Beijing, China (Y. Shu); Shantou University Medical College, Shantou, China (H. Zhu, Y. Guan); State Key Laboratory of Emerging Infectious Diseases, Shenzhen Third People's Hospital, Shenzhen, China (H. Zhu, Y. Guan, M. Peiris); The University of Hong Kong, Hong Kong, China (H. Zhu, Y. Guan, M. Peiris)

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Table 3

Influenza A(H7N9) virus replication in organs of inoculated birds*

Species Organ titer†
Brain Eye Trachea Lung Small intestine Large Intestine
Zebra finch < < 4.5 ± 0.0 (2/2) < < <
Society finch 2.5 ± 0.0 (1/2) 1.0 ± 0.0 (1/2) 4.6 ± 2.7 (2/2) 5.8 ± 0.0 (1/2) 1.0 ± 0.0 (1/2)‡ 2.5 ± 0.0 (1/2)
Sparrow < < < 1.0 ± 0.0 (1/1)‡ < <

*<, below the limit of detection (<0.75 EID50/mL.) EID50, 50% egg infectious dose.
†Log10 EID50/mL. Data are the mean ± SD of positive (>0.75 EID50/mL) samples (no. birds shedding/total no. sampled at the indicated time point).
‡Sample contained trace amount of virus: 1 or 2 of 3 inoculated eggs was positive at the lowest serial dilution.

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