Volume 20, Number 8—August 2014
Dispatch
Levofloxacin-Resistant Haemophilus influenzae, Taiwan, 2004–2010
Shu-Chen Kuo, Pei-Chen Chen, Yih-Ru Shiau, Hui-Ying Wang, Jui-Fen Lai, Wen Huang, and Tsai-Ling Yang Lauderdale
Table 3
Amino acid changes in GyrA and ParC quinolone resistance-determining regions of levofloxacin-resistant Haemophilus influenzae isolates, Taiwan, 2004–2010*
| Mutation profile no. | Change in GyrA |
Change in ParC |
No. isolates | |||
|---|---|---|---|---|---|---|
| S84 | D88 | S84 | E88 | |||
| 2 | – | N | I | – | 1 | |
| 3 | A | Y | I | – | 1 | |
| 4 | D | Y | I | – | 2 | |
| 5 | F | – | I | – | 1 | |
| 6 | F | G | I | – | 5 | |
| 7 | F | G | R | – | 1 | |
| 8 | F | N | I | – | 14 | |
| 9 | F | N | R | – | 2 | |
| 10 | F | Y | – | K | 1 | |
| 11 | F | Y | I | K | 16 | |
| 13 | L | – | R | K | 1 | |
| 14 | L | G | I | – | 23 | |
| 15 | L | G | I | K | 1 | |
| 16 | L | G | R | – | 41 | |
| 17 | L | N | – | – | 2 | |
| 18 | L | N | I | – | 42 | |
| 19 | L | N | R | – | 2 | |
| 20 | L | Y | – | K | 7 | |
| 21 | L | Y | I | – | 8 | |
| 22 | L | Y | I | K | 1 | |
| 23 | V | N | I | – | 7 | |
| 24 | Y | H | – | K | 1 | |
| 25 | Y | N | I | – | 1 | |
| 26 | Y | N | I | K | 1 | |
*PCR products were sequenced and sequences aligned by using Vector NTI (Invitrogen, Carlsbad, CA, USA). Amino acid codes: A, alanine; R, arginine; N, asparagine; D, aspartate; E, glutamate; G, glycine; H, histidine; I, isoleucine; L, leucine; K, lysine; F, phenylalanine; S, serine; Y, tyrosine; V, valine. –, no change.
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