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Volume 20, Number 9—September 2014
Research

Distance from Construction Site and Risk for Coccidioidomycosis, Arizona, USA

Janis E. BlairComments to Author , Yu-Hui H. Chang, Yvette Ruiz, Stacy Duffy, Beth E. Heinrich, and Douglas F. Lake1
Author affiliations: Mayo Clinic Hospital, Phoenix, Arizona, USA (J.E. Blair); Mayo Clinic, Scottsdale, Arizona (Y.-H. H. Chang, B.E. Heinrich); Arizona State University, Phoenix (Y. Ruiz, S. Duffy, D.F. Lake)

Main Article

Figure 2

Serial flow cytometry images showing immunologic conversion from negative to positive for participants in a study of distance from a construction site as a risk factor for coccidioidomycosis, Arizona, USA, 2012–2013.Conversion was measured by using the CD69 lymphocyte-activation assay. A, B) Images for a representative participant from campus A, which was adjacent to the construction site. C, D) Images for a representative participant from campus B, which was 13 miles from the construction site.

Figure 2. Serial flow cytometry images showing immunologic conversion from negative to positive for participants in a study of distance from a construction site as a risk factor for coccidioidomycosis, Arizona, USA, 2012–2013.Conversion was measured by using the CD69 lymphocyte-activation assay. A, B) Images for a representative participant from campus A, which was adjacent to the construction site. C, D) Images for a representative participant from campus B, which was 13 miles from the construction site. A, C) Images were done in 2012, before construction began. B, D) Images were done in 2013, a year after construction began. The participants’ CD3-positive T-cell populations are shown in the lower right quadrant of each image. The percentage of CD3/CD69-positive T cells changed from 1.9% to 6.4% in the campus A participant and from 2.9% to 17.7% in the campus B participant. FITC, fluorescein isothiocyanate; PE, phycoerythrin.

Main Article

1Preliminary findings from this study were presented at the 57th Annual Meeting of the Coccidioidomycosis Study Group, Pasadena, California, USA, April 6, 2013.

Page created: August 13, 2014
Page updated: August 13, 2014
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