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Volume 21, Number 11—November 2015
CME ACTIVITY - Synopsis

Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA

Dong Sik Jung1, Dimitrios Farmakiotis12, Ying Jiang, Jeffrey J. Tarrand, and Dimitrios P. KontoyiannisComments to Author 
Author affiliations: Dong-A University College of Medicine, Busan, South Korea (D.S. Jung); The University of Texas MD Anderson Cancer Center, Houston, Texas, USA (D.S. Jung, D. Farmakiotis, Y. Jiang, J.J. Tarrand, D.P. Kontoyiannis); Brigham and Women’s Hospital/Dana-Farber Cancer Institute, Boston, Massachusetts, USA (D. Farmakiotis)

Main Article

Table 4

Treatment and outcome of 68 cancer patients with candidemia caused by uncommon Candida species, Houston, Texas, USA*

Parameter Value
Antifungal treatment 66 (97)
Amphotericin B–based regimen 5 (8)
Echinocandin-based regimen 13 (20)
Azole-based monotherapy 12 (18)
Combination antifungal treatment
36 (55)
Median duration of treatment, d (range)
16 (0–76)
Catheter-related infection 17 (25)
C. guilliermondii 6 (35)
C. lusitaniae 7 (41)
C. famata 2 (12)
C. kefyr
2 (12)
Central venous catheter removal, no. patients/no. in category (%) 41/65 (63)
Median time to central venous catheter removal, d (range)
3 (0–21)
Resolution of neutropenia, no. patients/no. in category (%) 15/44 (34)
Persistent neutropenia† 24 (35)
Growth factors 42 (62)
Leukocyte transfusion 5 (7)
Abscess drainage 3 (4)
Crude mortality rate at 28 d
40 (61)
Mortality rate by Candida spp.,‡ no. patients/no. in category (%)
C. guilliermondii 16/27 (59)
C. lusitaniae 10/19 (53)
C. kefyr 10/13 (77)
C. famata 4/7 (57)

*Values are no. (%) patients except as indicated.
†Persistent neutropenia was defined as an absolute neutrophil count of <500/mcL for ≥7days.
‡No available data for C. dubliniensis.

Main Article

1These authors contributed equally to this article.

2Current affiliation: Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.

Page created: October 19, 2015
Page updated: October 19, 2015
Page reviewed: October 19, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
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