Volume 21, Number 11—November 2015
CME ACTIVITY - Synopsis
Uncommon Candida Species Fungemia among Cancer Patients, Houston, Texas, USA
Dong Sik Jung1, Dimitrios Farmakiotis12, Ying Jiang, Jeffrey J. Tarrand, and Dimitrios P. Kontoyiannis
Table 4
Treatment and outcome of 68 cancer patients with candidemia caused by uncommon Candida species, Houston, Texas, USA*
| Parameter | Value |
|---|---|
| Antifungal treatment | 66 (97) |
| Amphotericin B–based regimen | 5 (8) |
| Echinocandin-based regimen | 13 (20) |
| Azole-based monotherapy | 12 (18) |
| Combination antifungal treatment |
36 (55) |
| Median duration of treatment, d (range) |
16 (0–76) |
| Catheter-related infection | 17 (25) |
| C. guilliermondii | 6 (35) |
| C. lusitaniae | 7 (41) |
| C. famata | 2 (12) |
| C. kefyr |
2 (12) |
| Central venous catheter removal, no. patients/no. in category (%) | 41/65 (63) |
| Median time to central venous catheter removal, d (range) |
3 (0–21) |
| Resolution of neutropenia, no. patients/no. in category (%) | 15/44 (34) |
| Persistent neutropenia† | 24 (35) |
| Growth factors | 42 (62) |
| Leukocyte transfusion | 5 (7) |
| Abscess drainage | 3 (4) |
| Crude mortality rate at 28 d |
40 (61) |
| Mortality rate by Candida spp.,‡ no. patients/no. in category (%) | |
| C. guilliermondii | 16/27 (59) |
| C. lusitaniae | 10/19 (53) |
| C. kefyr | 10/13 (77) |
| C. famata | 4/7 (57) |
*Values are no. (%) patients except as indicated.
†Persistent neutropenia was defined as an absolute neutrophil count of <500/mcL for ≥7days.
‡No available data for C. dubliniensis.
1These authors contributed equally to this article.
2Current affiliation: Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Page created: October 19, 2015
Page updated: October 19, 2015
Page reviewed: October 19, 2015
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