Volume 21, Number 12—December 2015
Dispatch
Influenza A(H6N1) Virus in Dogs, Taiwan
Table 2
Molecular characterization of A/canine/Taiwan/E01/2014 (H6N1) influenza virus and 2 other influenza viruses, Taiwan*
| Gene, amino acid substitution | Virus |
Function | ||
|---|---|---|---|---|
| A/canine/Taiwan/E01/2014 | A/Taiwan/2/2013 | A/mallard/San-Jiang/275/2007 | ||
| PB2 | ||||
| E627K | K | E | E | Replication ability in mammalian host |
| D701Q |
D |
D |
D |
Nuclear import |
| PB1-F2 | ||||
| N66S |
N |
Truncated form |
S |
Induction of apoptosis |
| HA | ||||
| Cleavage site | Single basic amino acid (PQIATR†G) | Single basic amino acid (PQIATR†G) | Single basic amino acid (PQIETR†G) | HA cleavage |
| Q226L | Q | Q | Q | Increased virus binding ability of α2–6 sialic acid receptor |
| G228S |
S |
S |
G |
|
| NA | ||||
| H275Y | H | H | H | Oseltamivir resistance |
| 41–52 and 68–69
deletions |
Deleted |
Deleted |
Complete |
Adaptation hallmark of waterfowl viruses to terrestrial poultry |
| M2 | ||||
| S31N |
N |
N |
S |
Adamantane resistance |
| NS1 | ||||
| D92E | D | D | D | Unknown |
| EPEV sequence (C-terminus) | EPEV | EPEV | ESEV | PDZ ligand domain |
*PB, polymerase basic; HA, hemagglutinin; NA, neuraminidase; M, matrix; NS, nonstructural protein.
†HA cleavage site.
1These authors contributed equally to this article.
Page created: November 17, 2015
Page updated: November 17, 2015
Page reviewed: November 17, 2015
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