Volume 21, Number 12—December 2015
Research
Zoonotic Leprosy in the Southeastern United States
Table 2
Next-generation whole-genome sequencing of Mycobacterium leprae strain 3I-2-v15 derived from wild armadillos from the southeastern United States compared with that for armadillo-associated strain 3I-2-v1
Sample no. | Average coverage (% genome covered)* | No. variants partially shared† | No. variants only in 3I-2-v15‡ | No. 3I-2 variants absent in 3I-2-v15‡ | No. variants in both strains | No. TN strain variants in both strains |
---|---|---|---|---|---|---|
US-36 | 19.8 (88.72) | 7 | 9 | 4 | 20 | 37 |
US-95 | 97.99 (98.36) | 1 | 9 | 4 | 14 | 37 |
FL-26 | 119.32 (99.00) | 0 | 9 | 4 | 13 | 37 |
MRI-9 | 25.3 (92.08) | 6 | 9 | 4 | 19 | 37 |
*Average no. of consensus sequence reads obtained from the particular specimen covering the entire genome.
†No. variants reported to be specific for single-nucleotide polymorphism (SNP) type 3I-2 that are present in all samples of the 3I-2-v1 genotype and that were found in some, but not all, samples of the 3I-2-v15 genotype.
‡Resequencing referenced the M. leprae TN standard genomic sequence, identified 13 variants present only in 3I-2-v1 (2 SNP, 2 insertion/deletions) or 3I-2-v15 (9 SNP), and differentiated the strains.