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Volume 21, Number 12—December 2015

Zoonotic Leprosy in the Southeastern United States

Rahul Sharma, Pushpendra Singh, W.J. Loughry, J. Mitchell Lockhart, W. Barry Inman, Malcolm S. Duthie, Maria T. Pena, Luis A. Marcos, David M. Scollard, Stewart T. Cole, and Richard W. TrumanComments to Author 
Author affiliations: National Hansen’s Disease Program, Baton Rouge, Louisiana, USA (R. Sharma, P. Singh, M.T. Pena, D.M. Scollard, R.W. Truman); Louisiana State University School of Veterinary Medicine, Baton Rouge (R. Sharma, P. Singh, M.T. Pena); Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland (P. Singh, S.T. Cole); Valdosta State University, Valdosta, Georgia, USA (W.J. Loughry, J.M. Lockhart); Florida Department of Health, Merritt Island, Florida, USA (W.B. Inman); Infectious Disease Research Institute, Seattle, Washington, USA (M.S. Duthie); Hattiesburg Clinic, Hattiesburg, Mississippi, USA (L.A. Marcos)

Main Article

Table 2

Next-generation whole-genome sequencing of Mycobacterium leprae strain 3I-2-v15 derived from wild armadillos from the southeastern United States compared with that for armadillo-associated strain 3I-2-v1

Sample no. Average coverage (% genome covered)* No. variants partially shared† No. variants only in 3I-2-v15‡ No. 3I-2 variants absent in 3I-2-v15‡ No. variants in both strains No. TN strain variants in both strains
US-36 19.8 (88.72) 7 9 4 20 37
US-95 97.99 (98.36) 1 9 4 14 37
FL-26 119.32 (99.00) 0 9 4 13 37
MRI-9 25.3 (92.08) 6 9 4 19 37

*Average no. of consensus sequence reads obtained from the particular specimen covering the entire genome.
†No. variants reported to be specific for single-nucleotide polymorphism (SNP) type 3I-2 that are present in all samples of the 3I-2-v1 genotype and that were found in some, but not all, samples of the 3I-2-v15 genotype.
‡Resequencing referenced the M. leprae TN standard genomic sequence, identified 13 variants present only in 3I-2-v1 (2 SNP, 2 insertion/deletions) or 3I-2-v15 (9 SNP), and differentiated the strains.

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Page created: October 29, 2015
Page updated: October 29, 2015
Page reviewed: October 29, 2015
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