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Volume 21, Number 3—March 2015
Dispatch

Reassortant Highly Pathogenic Influenza A(H5N6) Virus in Laos

Frank Y.K. WongComments to Author , Phouvong Phommachanh, Wantanee Kalpravidh, Chintana Chanthavisouk, Jeffrey Gilbert, John Bingham, Kelly R. Davies, Julie Cooke, Debbie Eagles, Sithong Phiphakhavong, Songhua Shan, Vittoria Stevens, David T. Williams, Phachone Bounma, Bounkhouang Khambounheuang, Christopher Morrissy, Bounlom Douangngeun, and Subhash Morzaria
Author affiliations: Commonwealth Scientific and Industrial Research Organisation Australian Animal Health Laboratory, Geelong, Victoria, Australia (F.Y.K. Wong, J. Bingham, K.R. Davies, J. Cooke, D. Eagles, S. Shan, V. Stevens, D.T. Williams, C. Morrissy); National Animal Health Laboratory, Vientiane, Laos (P. Phommachanh, B. Douangngeun); Ministry of Agriculture and Forestry, Vientiane (S. Phiphakhavong, P. Bounma, B. Khambounheuang); Food and Agricultural Organization of the United Nations Regional Office for Asia and the Pacific, Bangkok, Thailand (W. Kalpravidh, C. Chanthavisouk, J. Gilbert, S. Morzaria)

Main Article

Table 1

Amino acid substitutions in translated mature HA1 proteins of influenza A(H5N6) virus from Laos and H5 clade 2.3.4 reference viruses*

Mature HA1 position (H5 numbering)† H5 subtype virus clade‡
DK/LAO/XBY4 (H5N6) 2.3.4.6 DK/GD/GD01 (H5N6) 2.3.4.6 WD/SD/628 (H5N1) 2.3.4.6 CK/LAO/XNY26 (H5N1) 2.3.4 JWE/HK/1038 (H5N1) 2.3.4 DK/LAO/3295 (H5N1) 2.3.4 ANH/1 (H5N1) 2.3.4
40 R R K K K K K
45 N N N D D D D
53 K K K R R R R
72 R R R N N N N
82 R R R K K K K
95 L L L F F F F
114 T T I I I I I
115 L L L Q Q Q Q
123 P P P S S S S
124 N N D D D D D
127 T T T A A A A
129 L L L S S S S
133 A A A S S S S
140 M M A T T T T
151 T T I I I I I
155 D N D N N N N
156 A A A T K T T
162 M M I R R R R
169 R R R Q Q Q Q
183 N N N D D D D
189 N N N K K K K
192 K K K Q Q Q Q
198 V V V I I I I
210 E V V V V V V
218 Q Q Q K K K K
223 R R R S S S S
240 H H H N N N N
263 T T T A A A A
265 M M M M M I V
269 M M V V V V V
273 H H H N N N N

*HA, hemagglutinin.
†Sites associated with antigenicity are indicated in boldface (not comprehensive) (11).
‡Virus names: DK/LAO/XBY4, A/duck/Laos/XBY004/2014; DK/GD/GD01, A/duck/Guangdong/GD01/2014; WD/SD/628, A/wild duck/Shandong/628/2011; CK/LAO/XNY26, A/chicken/Laos/Xaythiani-26/2006; JWE/HK/1038, A/Japanese white-eye/Hong Kong/1038/2006; DK/LAO/3295, A/duck/Laos/3295/2006; ANH/1, A/Anhui/1/2005. Clade designations provided by the World Health Organization/World Organisation for Animal Health/Food and Agricultural Organization of the United Nations H5N1 Evolution Working Group unified nomenclature system for highly pathogenic avian influenza (H5N1) viruses (http://www.who.int/influenza/gisrs_laboratory/h5n1_nomenclature/en/). Proposed clade 2.3.4.6 has not been formally recognized.

Main Article

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Page updated: February 18, 2015
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