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Volume 21, Number 3—March 2015
Dispatch

Reassortant Highly Pathogenic Influenza A(H5N6) Virus in Laos

Frank Y.K. WongComments to Author , Phouvong Phommachanh, Wantanee Kalpravidh, Chintana Chanthavisouk, Jeffrey Gilbert, John Bingham, Kelly R. Davies, Julie Cooke, Debbie Eagles, Sithong Phiphakhavong, Songhua Shan, Vittoria Stevens, David T. Williams, Phachone Bounma, Bounkhouang Khambounheuang, Christopher Morrissy, Bounlom Douangngeun, and Subhash Morzaria
Author affiliations: Commonwealth Scientific and Industrial Research Organisation Australian Animal Health Laboratory, Geelong, Victoria, Australia (F.Y.K. Wong, J. Bingham, K.R. Davies, J. Cooke, D. Eagles, S. Shan, V. Stevens, D.T. Williams, C. Morrissy); National Animal Health Laboratory, Vientiane, Laos (P. Phommachanh, B. Douangngeun); Ministry of Agriculture and Forestry, Vientiane (S. Phiphakhavong, P. Bounma, B. Khambounheuang); Food and Agricultural Organization of the United Nations Regional Office for Asia and the Pacific, Bangkok, Thailand (W. Kalpravidh, C. Chanthavisouk, J. Gilbert, S. Morzaria)

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Table 2

Hemagglutination inhibition assay of influenza A(H5N6) virus from Laos with chicken and ferret antisera against reference influenza A(H5N1) viruses*

CK/VNM/8 (H5N1) 1 CK/IND/BBVM204 (H5N1) 2.1.3 PH/VNM/3773 (H5N1) 2.3.2.1c CK/LAO/XNY26 (H5N1) 2.3.4 CK/MYM/295 (H5N1) 2.3.2.1a DK/LAO/XBY4 (H5N6) 2.3.4.6 CK NEG
Reference
CK/VNM/8 1 640 20 40 80 80 80 <10
CK/IND/BBVM204 2.1.3 10 1,280 20 10 20 20 <10
PH/VNM/3773 2.3.2.1c 80 80 640 80 320 320 <10
CK/LAO/XNY26 2.3.4 160 80 40 320 160 80 <10
CK/MYM/295 2.3.2.1a 80 40 160 20 320 20 <10
Test
CK/LAO/LPQ1 2.3.4.6 <10 <10 <10 <10 <10 320 <10
DK/LAO/LPQ2 2.3.4.6 <10 <10 <10 <10 <10 320 <10
CK/LAO/XBY3 2.3.4.6 <10 <10 <10 <10 <10 320 <10
DK/LAO/XBY4
 2.3.4.6
 40
 <10
 10
 <10
 <10
 640
 <10
Reference ferret antiserum‡
JWE/HK/1038 (H5N1) 2.3.4
 DK/LAO/3295 (H5N1) 2.3.4
 ANH/1 (H5N1) 2.3.4
 CM/HK/5052 (H5N1) 2.3.2.1
 BS/HK/1161 (H5N1) 2.3.2.1b
 HUB/1 (H5N1) 2.3.2.1a
 DK/VNM/2848 (H5N1) 2.3.2.1c
Reference
JWE/HK/1038 2.3.4 80 80 80 <40 <40 ND ND
DK/LAO/3295 2.3.4 <40 160 80 <40 <40 <40 <40
ANH/1 2.3.4 <40 320 320 <40 <40 <40 <40
CM/HK/5052 2.3.2.1 <40 40 80 160 <40 <40 80
BS/HK/1161 2.3.2.1b <40 <40 80 80 320 <40 80
HUB/1 2.3.2.1a <40 <40 40 80 <40 80 40
DK/VNM/2848 2.3.2.1c <40 <40 <40 40 160 <40 160
Test
CK/LAO/LPQ1 2.3.4.6 <40 <40 <40 <40 <40 <40 <40
DK/LAO/LPQ2 2.3.4.6 <40 <40 <40 <40 <40 <40 <40
CK/LAO/XBY3 2.3.4.6 <40 <40 <40 <40 <40 <40 <40
DK/LAO/XBY4 2.3.4.6 <40 <40 40 <40 <40 <40 <40

*Virus names: CK/VNM/8, A/chicken/Vietnam/8/2004; CK/IND/BBVM204, A/chicken/Indonesia/ BBVM204/2007; PH/VNM/3773, A/pheasant/Vietnam/3773/2013; CK/LAO/XNY26, A/chicken/Laos/Xaythiani-26/2006; CK/MYM/295, A/chicken/Myanmar/295/2010; JWE/HK/1038, A/Japanese white-eye/Hong Kong/1038/2006; DK/LAO/3295, A/duck/Laos/3295/2006; ANH/1, A/Anhui/1/2005; CM/HK/5052, A/common magpie/Hong Kong/5052/2007; BS/HK/1161, A/barn swallow/Hong Kong/1161/2010; HUB/1, A/Hubei/1/2010; DK/VNM/2848, A/duck/Vietnam/NCVD-2848/2013; CK/LAO/LPQ1, A/chicken/Laos/LPQ001/2014; DK/LAO/LPQ2, A/duck/Laos/LPQ002/2014; CK/LAO/XBY3, A/chicken/Laos/XBY003/2014; DK/LAO/XBY4, A/duck/Laos/XBY004/2014; CK NEG, negative control chicken serum.
†Clade designations provided by the World Health Organization/World Organisation for Animal Health/Food and Agricultural Organization of the United Nations H5N1 Evolution Working Group unified nomenclature system for highly pathogenic avian influenza (H5N1) viruses (http://www.who.int/influenza/gisrs_laboratory/h5n1_nomenclature/en/). Proposed clade 2.3.4.6 has not been formally recognized.
‡Values are titers. Homologous titers of reference virus antigen to its corresponding antiserum are indicated in boldface.

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Page created: February 18, 2015
Page updated: February 18, 2015
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