Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 21, Number 5—May 2015
Research

Molecular Epidemiology of Plasmodium falciparum Malaria Outbreak, Tumbes, Peru, 2010–2012

G. Christian BaldevianoComments to Author , Sheila Akinyi Okoth, Nancy Arrospide, Rommell V. Gonzalez, Juan F. Sánchez, Silvia Macedo, Silvia Conde, L. Lorena Tapia, Carola Salas, Dionicia Gamboa, Yeni Herrera, Kimberly A. Edgel, Venkatachalam Udhayakumar, and Andrés G. Lescano
Author affiliations: US Naval Medical Research Unit No. 6, Callao, Peru (G.C. Baldeviano, J.F. Sánchez, S. Macedo, L.L. Tapia, C. Salas, K.A. Edgel, A.G. Lescano); Centers for Disease Control and Prevention, Atlanta, Georgia, USA (S. Akinyi Okoth, V. Udhayakumar); Instituto Nacional de Salud del Peru, Lima, Peru (N. Arrospide); Direccion Regional de Salud de Tumbes, Tumbes, Peru (R.V. Gonzalez, S. Conde); Universidad Peruana Cayetano Heredia, Lima (D. Gamboa); Ministry of Health of Peru, Lima (Y. Herrera)

Main Article

Table 2

Drug resistant allele haplotypes of representative Plasmodium falciparum isolates from the Tumbes outbreak, clonets A–E, and isolates from the Amazon region, Peru, 2010–2012*

Code Collection date Source Gene haplotypes
Pfdhfr Pfcrt Pfdhps Pfmdr1 Pfhrp2
MIS 0760 2010 Oct 25 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
MIS 0761 2010 Oct 26 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
MIS 1142 2011 Mar 31 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
MIS 1147 2011 Jul 19 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
MIS 1146 2011 Jul 26 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
MIS 1168 2011 Aug 19 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
MIS1280 2011 Aug 27 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
TI-435 2011 Sep 22 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
TIA-4156 2011 Sep 28 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
T3–861 2011 Oct 4t Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
TIA-4333 2011 Oct 14t Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
MIS1278 2011 Nov 1 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
T3–989 2011 Nov 18 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
M01L1615 2011 Dec 1 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
TIA-434 2011 Dec 1 Tumbes 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
PSSI-205 2011 Dec 27 Corrales 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
Z1–22 2012 Mar 14 Zarumilla 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
PR-12 2009 Dec 17 Requena 50R/51I/108N SVMNT 437G/540E/581G 184F/1034C/1042D/1246Y Neg
PY013 2010 Mar Yurimaguas ND ND ND ND Neg
Clonet B 1999–2000 Loreto (E) 51I/108N/164I SVMNT 437G/581G 184F/1042D and 184F/1034C/1042D/1246Y 4/18
Clonet A 1999–2000 Loreto (E) 51I/108N/164I SVMNT WT, 437G/581G, and 437G/540E/581G 184F/1034C/1042D and 184F/1034C/1042D/1246Y 1/24
Clonet C 1999–2000 Loreto (E, W) 108N CVMNT WT 184F/1034C/1042D 5/25
Clonet D 1999–2000 Loreto (E, W) 108N CVMNT 540-SYN 184F/1034C/1042D and 184F/1034C/1042D/1246Y 9/15
Clonet E 1999–2000 Zarumilla WT and 108N CVMNT WT ND Pos

*Only representative alleles are included in this table. Gene haplotypes are indicated by numbers where a mutated amino acid was found. C, central Amazon; E, eastern Amazon; W, western Amazon; neg, Pfhrp2 negative; pos, Pfhrp2 positive, 1/24, 1 of 24 isolates positive for Pfhrp2; ND, not determined; WT, wild type.

Main Article

Page created: April 17, 2015
Page updated: April 17, 2015
Page reviewed: April 17, 2015
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external