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Volume 21, Number 8—August 2015
Research

Estimates of Outbreak Risk from New Introductions of Ebola with Immediate and Delayed Transmission Control

Damon J.A. TothComments to Author , Adi V. Gundlapalli, Karim Khader, Warren B.P. Pettey, Michael Rubin, Frederick R. Adler, and Matthew H. Samore
Author affiliations: University of Utah, Salt Lake City, Utah, USA (D.J.A. Toth, A.V. Gundlapalli, K. Khader, W.B.P. Pettey, M.A. Rubin, F.R. Adler, M.H. Samore); US Department of Veterans Affairs Salt Lake City Health Care System, Salt Lake City (D.J.A. Toth, A.V. Gundlapalli, K. Khader, W.B.P. Pettey, M.A. Rubin, M.H. Samore).

Main Article

Table 1

Characteristics of Ebola case-patients reported outside Guinea, Sierra Leone, and Liberia*

Case-patients Year and month Country Circumstance of infection No. transmissions
1 2014 Jul Nigeria Imported by traveler 13
2–4 2014 Jul–Aug Nigeria Locally acquired 1
5–19 2014 Jul–Aug Nigeria Locally acquired 0
20 2014/Aug Nigeria Locally acquired 3
21–23 2014/Aug Spain, United Kingdom, Germany Evacuated 0
24 2014/Aug Senegal Imported by traveler 0
25–27 2014/Aug–Sep United States Evacuated 0
28 2014/Sep France Evacuated 0
29 2014/Sep United States Imported by traveler 2
30 2014/Sep Spain Evacuated 1
31–32 2014/Oct United States Locally acquired 0
33 2014/Oct Spain Locally acquired 0
34–35 2014/Oct Germany Evacuated 0
36 2014/Oct Norway Evacuated 0
37 2014/Oct United States Imported by traveler 0
38 2014/Oct Mali Imported by traveler 0
39–40 2014/Oct–Nov United States Evacuated 0
41 2014/Nov France Evacuated 0
42 2014/Nov Mali Imported by traveler 5
43–44 2014/Nov Mali Locally acquired 1
45–49 2014/Nov Mali Locally acquired 0
50–52 2014/Nov United States, Switzerland, Italy Evacuated 0
53 2014/Dec The Netherlands Evacuated 0
54 2014/Dec United Kingdom Imported by traveler 0
55–56 2015/Mar United Kingdom, United States Evacuated 0

*These data are published and publicly available as of April 24, 2015. Month/year is when patients were transferred or diagnosed. References by country: Nigeria (5,6); Spain (15,16); United Kingdom (14,15); Senegal (12);United States (7,8,13,15); Mali (9–11); other countries (15).

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References
  1. Baize  S, Pannetier  D, Oestereich  L, Rieger  T, Koivogui  L, Magassouba  N, Emergence of Zaire Ebola virus disease in Guinea. N Engl J Med. 2014;371:1418–25. DOIPubMedGoogle Scholar
  2. Centers for Disease Control and Prevention. 2014 Ebola outbreak in West Africa—outbreak distribution map. 2015 Apr 17 [cited 2015 Apr 24]. http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/distribution-map.html
  3. Centers for Disease Control and Prevention. Outbreaks chronology: Ebola virus disease. 2015 Apr 24 [cited 2015 Apr 24]. http://www.cdc.gov/vhf/ebola/outbreaks/history/chronology.html
  4. Gomes  MFC, Postore y Piontti  A, Rossi  L, Chao  D, Longini  I, Halloran  ME, Assessing the international spreading risk associated with the 2014 West African Ebola outbreak. PLoS Curr Outbreaks. 2014 Sep 2. Edition 1. http://dx.doi.org/10.1371/currents.outbreaks.cd818f63d40e24aef769dda7df9e0da5
  5. Fasina  FO, Shittu  A, Lazarus  D, Tomori  O, Simonsen  L, Viboud  C, Transmission dynamics and control of Ebola virus disease outbreak in Nigeria, July to September 2014. Euro Surveill. 2014;19:20920.PubMedGoogle Scholar
  6. Shuaib  F, Gunnala  R, Musa  EO, Mahoney  FJ, Oguntimehin  O, Nguku  PM, Ebola virus disease outbreak—Nigeria, July–September 2014. MMWR Morb Mortal Wkly Rep. 2014;63:867–72.PubMedGoogle Scholar
  7. McCarty  CL, Basler  C, Karwowski  M, Erme  M, Nixon  G, Kippes  C, Response to importation of a case of Ebola virus disease—Ohio, October 2014. MMWR Morb Mortal Wkly Rep. 2014;63:1089–91.PubMedGoogle Scholar
  8. Chevalier  MS, Chung  W, Smith  J, Weil  LM, Hughes  SM, Joyner  SN, Ebola virus disease cluster in the United States—Dallas County, Texas, 2014. MMWR Morb Mortal Wkly Rep. 2014;63:1087–8.PubMedGoogle Scholar
  9. World Health Organization. Mali: details of the additional cases of Ebola virus disease. 2014 Nov 20 [cited 2015 Apr 24]. http://www.who.int/mediacentre/news/ebola/20-november-2014-mali/en/
  10. World Health Organization. Mali confirms 2 new cases of Ebola virus disease. 2014 Nov 25 [cited 2015 Apr 24]. http://www.who.int/mediacentre/news/ebola/25-november-2014-mali/en/
  11. World Health Organization. Mali case, Ebola imported from Guinea. 2014 Nov 10 [cited 2015 Apr 24]. http://www.who.int/mediacentre/news/ebola/10-november-2014-mali/en/
  12. Mirkovic  K, Thwing  J, Diack  PA. Importation and containment of Ebola virus disease— Senegal, August–September 2014. MMWR Morb Mortal Wkly Rep. 2014;63:873–4.PubMedGoogle Scholar
  13. Centers for Disease Control and Prevention. Cases of Ebola diagnosed in the United States. 2014 Dec 16 [cited 2015 Apr 24]. http://www.cdc.gov/vhf/ebola/outbreaks/2014-west-africa/united-states-imported-case.html
  14. Jenkins  L. Nurse who contracted Ebola released from hospital. 2015 Jan 24 [cited 2015 Apr 24]. http://www.theguardian.com/world/2015/jan/24/ebola-pauline-cafferkey-recovery-discharge
  15. Public Health England. Ebola virus disease epidemiological update: no. 32. 2015 Apr 24 [cited 2015 Apr 24]. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/423997/EVD_Epidemiological_Update_24_April.pdf.
  16. Gulland  A. Spanish authorities investigate how nurse contracted Ebola. BMJ. 2014;349:g6120. DOIPubMedGoogle Scholar
  17. Szabo  L. Costs of responding to Ebola adding up. 2014 Nov 25 [cited 2015 Apr 24]. http://www.usatoday.com/story/news/nation/2014/11/25/ebola-costs-add-up/19346913/
  18. Rainisch  G, Asher  J, George  D, Clay  M, Smith  TL, Cosmos  K, Estimating Ebola treatment needs, United States [letter]. Emerg Infect Dis. 2015 Jul [cited 2015 Apr 27].
  19. Farrington  CP, Grant  AD. The distribution of time to extinction in subcritical branching processes: applications to outbreaks of infectious disease. J Appl Probab. 1999;36:771–9. DOIGoogle Scholar
  20. Becker  N. On parametric estimation for mortal branching processes. Biometrika. 1974;61:393–9. DOIGoogle Scholar
  21. Nishiura  H, Yan  P, Sleeman  CK, Mode  CJ. Estimating the transmission potential of supercritical processes based on the final size distribution of minor outbreaks. J Theor Biol. 2012;294:48–55. DOIPubMedGoogle Scholar
  22. Blumberg  S, Lloyd-Smith  JO. Inference of R0 and transmission heterogeneity from the size distribution of stuttering chains. PLOS Comput Biol. 2013;9:e1002993. DOIPubMedGoogle Scholar
  23. Ferguson  NM, Fraser  C, Donnelly  CA, Ghani  AC, Anderson  RM. Public health risk from the avian H5N1 influenza epidemic. Science. 2004;304:968–9. DOIPubMedGoogle Scholar
  24. Jansen  VAA, Stollenwerk  N, Jensen  HJ, Ramsay  ME, Edmunds  WJ, Rhodes  CJ. Measles outbreaks in a population with declining vaccine uptake. Science. 2003;301:804. DOIPubMedGoogle Scholar
  25. Lloyd-Smith  JO, Schreiber  SJ, Kopp  PE, Getz  WM. Superspreading and the effect of individual variation on disease emergence. Nature. 2005;438:355–9. DOIPubMedGoogle Scholar
  26. DiCiccio  T, Efron  B. Bootstrap confidence intervals. Stat Sci. 1996;11:189–228 .DOIGoogle Scholar
  27. Arnold  TB, Emerson  JW. Nonparametric goodness-of-fit tests for discrete null distributions. R J. 2011;3/2:34–9.
  28. Consul  PC, Shenton  LR. Use of Lagrange expansion for generating discrete generalized probability distributions. SIAM J Appl Math. 1972;23:239–48. DOIGoogle Scholar
  29. Consul  PC, Famoye  F. Lagrangian probability distributions. Boston: Birkhauser; 2006.
  30. Centers for Disease Control and Prevention. Interim guidance for U.S. hospital preparedness for patients under investigation (PUIs) or with confirmed Ebola virus disease (EVD): a framework for a tiered approach. 2015 Feb 20 [cited 2015 Apr 24]. http://www.cdc.gov/vhf/ebola/hcp/us-hospital-preparedness.html
  31. Althaus  CL. Ebola superspreading: the real lessons from HIV scale-up. Lancet Infect Dis. 2015;15:507–8. DOIPubMedGoogle Scholar
  32. Faye  O, Boelle  P, Heleze  E, Faye  O, Loucoubar  C, Magassouba  N, Chains of transmission and control of Ebola virus disease in Conakry, Guinea, in 2014: an observational study. Lancet Infect Dis. 2015;15:320–6. DOIPubMedGoogle Scholar
  33. Bogoch  II, Creatore  MI, Cetron  MS, Brownstein  JS, Pesik  N, Miniota  J, Assessment of the potential for international dissemination of Ebola virus via commercial air travel during the 2014 west African outbreak. Lancet. 2015;385:29–35. DOIPubMedGoogle Scholar
  34. Rainisch  G, Shankar  M, Wellman  M, Merlin  T, Meltzer  MI. Regional spread of Ebola virus, West Africa, 2014. Emerg Infect Dis. 2015;21:444–7. DOIPubMedGoogle Scholar
  35. Chowell  D, Castillo-Chavez  C, Krishna  S, Qiu  X, Anderson  KS. Modelling the effect of early detection of Ebola. Lancet Infect Dis. 2015;15:148–9. DOIPubMedGoogle Scholar

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