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Volume 21, Number 9—September 2015
Emerging Infections Program

Encephalitis Surveillance through the Emerging Infections Program, 1997–2010

Karen C. BlochComments to Author  and Carol A. Glaser
Author affiliations: Vanderbilt University, Nashville, Tennessee, USA (K.C. Bloch); Kaiser Permanente, Oakland, California, USA (C.A. Glaser)

Main Article

Table 3

Emerging Infections Program Encephalitis Project clinical profiles, 1997–2010*

Clinical profile Patient description Comments
Temporal lobe Temporal lobe enhancement on imaging or activity on EEG HSV accounted for approximately one third of cases
Extrapyramidal Movement disorder Measles (SSPE), autoimmune encephalitides
Ataxia or gait disorder, or focal cerebellar lesion on imaging
Acute EBV infection seen in a minority of cases
Cerebral edema Neuroimaging showing diffuse brain edema Deaths exceed 70%
Intractable seizures Seizures requiring anesthetic coma for management Majority of case-patients: pediatric patients with prolonged hospitalization
Seizure with rapid recovery Onset with seizure and return to baseline mental status in <96 h CSF typically bland; Bartonella spp. most common cause (cat-scratch encephalopathy)
Psychosis New onset of prominent psychiatric symptoms Anti-NMDAR antibodies common in this syndrome

*EEG, electroencephalogram; HSV, herpes simplex virus; SSPE, subacute sclerosing panencephalitis; EBV, Epstein-Barr virus; NMDAR, anti-N-methyl-D-asparate receptor.

Main Article

Page created: August 14, 2015
Page updated: August 14, 2015
Page reviewed: August 14, 2015
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