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Volume 22, Number 10—October 2016
Research

Whole-Genome Characterization of Epidemic Neisseria meningitidis Serogroup C and Resurgence of Serogroup W, Niger, 2015

Cecilia B. Kretz1, Adam C. Retchless1, Fati Sidikou, Bassira Issaka, Sani Ousmane, Stephanie Schwartz, Ashley H. Tate, Assimawè Pana, Berthe-Marie Njanpop-Lafourcade, Innocent Nzeyimana, Ricardo Obama Nse, Ala-Eddine Deghmane, Eva Hong, Ola Brønstad Brynildsrud, Ryan T. Novak, Sarah A. Meyer, Odile Ouwe Missi Oukem-Boyer, Olivier Ronveaux, Dominique A. Caugant, Muhamed-Kheir Taha, Xin WangComments to Author , and the Niger Response Team
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (C.B. Kretz, A.C. Retchless, S. Schwartz, A.H. Tate, R.T. Novak, S.A. Meyer, X. Wang); Centre de Recherche Médicale et Sanitaire, Niamey, Niger (F. Sidikou, B. Issaka, S. Ousmane, O.O.M. Oukem-Boyer); Agence de Médecine Préventive, Paris (B. Njanpop-Lafourcade); World Health Organization, Niamey (I. Nzeyimana, A. Pana, R. Obama Nse); Institut Pasteur, Paris, France (A.-E. Deghmane, E. Hong, M.-K. Taha); Norwegian Institute of Public Health, Oslo, Norway (O.B. Brynildsrud, D.A. Caugant); World Health Organization, Geneva, Switzerland (O. Ronveaux)

Main Article

Table

Summary of molecular typing and serogroups of Neisseria meningitidis isolates, Niger, 2015*

Serogroup No. isolates ST/CC PorA† PorB† FetA† NadA‡ NhbA§ FHbp¶ gyrA§ penA§ rpoB§
C 81 ST-10217/NA P1.21–15,16 3–463 1–7 Not present 798 27/A106 2 22 1
W 14 ST-11/CC11 P1.5,2 2–2 1–1 2/3.6 96 9/B45 4 1 9
W 6 ST-11/CC11 P1.5,2 2–277 1–84 2/3.6 96 9/B45 4 1 9
W
 1
 ST-11/CC11
 P1.5,2
 2–60
 1–1
 2/3.6
 96
 841/B#
 4
 1
 9
*ST and CC are derived from multilocus sequence typing. CC, clonal complex; NA, not assigned; ST, sequence type.
†PorA, PorB, and FetA are typed according to their respective variable regions.
‡NadA is categorized by Novartis conventions of variant and peptide identifier.
§The alleles for gyrA, penA, and rpoB are identified by PubMLST DNA allele identifiers (http://pubmlst.org/). NhbA is identified by PubMLST peptide identifier.
¶FHbp is identified by the PubMLST peptide identifier and the Pfizer peptide identifier (subfamilies A and B). Assignment of Pfizer peptide identifier is pending for peptide 841.

Main Article

1These first authors contributed equally to this article.

2Members of the Niger Response Team who contributed to this study are listed at the end of this article.

Page created: September 20, 2016
Page updated: September 20, 2016
Page reviewed: September 20, 2016
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