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Volume 22, Number 12—December 2016

Dispatch

Horizontal Transmission of Chronic Wasting Disease in Reindeer

S. Jo Moore, Robert Kunkle, M. Heather West Greenlee, Eric Nicholson, Jürgen Richt, Amir Hamir1, W. Ray Waters, and Justin GreenleeComments to Author 
Author affiliations: US Department of Agriculture, Ames, Iowa, USA (S.J. Moore, R. Kunkle, E. Nicholson, J. Richt, A. Hamir, W.R. Waters, J. Greenlee):; Iowa State University, Ames (M.H. West Greenlee)

Main Article

Table 2

Resutls of tissue testing for chronic wasting disease in reindeer based on immunohistochemical detection of PrPSc, assessment of spongiform change in formalin-fixed tissues, or both*

Group no./animal no. Survival time,¶ mpi Clinical features CNS tissues†
Retina‡ Other tissues§
Spinal cord Obex Cerebellum Midbrain Thalamus Neocortex Lymphoid head Lymphoid other Rectal mucosa Pituitary Spleen Intestines Skeletal muscle Heart Peripheral nervous system Kidney Gut tube Adrenal
1
1 2.6# FD NA/NA −/− −/− −/− −/− −/− NA NA NA NA NA NA NA NA NA
2 20.9 LBC, FD +/+ +/+ −/− −/+ +/+ +/+ + + + + + + + + +
3 33.9 FD +/+ +/+ +/+ +/+ +/+ +/+ + + + + + + + +
4 34.1 Seizures +/+ +/+ +/+ +/+ +/+ +/+ + + + + + + +
5
53.3
FD
−/+
+/+
−/+
+/+
+/+
−/−
+
+
+
+
+
NA

NA
NA

NA
NA
NA
2
6 24.7 FD −/+ +/+ −/− +/+ +/+ −/− + + + + + + + + +
7 36.4 FD −/− −/− −/− −/− −/− −/− + +
8 38.7 REC +/+ +/+ +/+ +/+ +/+ +/+ + + + + + + + +
9 41.7 REC +/+ −/+ −/+ +/+ NA/ NA +/+ + + +
10
42.2
LTH, FD
−/−
+/+
−/+
+/+
+/+
−/−
+
+
NA
+
+
+

NA
NA

NA
NA
NA
3
11 13.7# FD −/− −/− −/− −/− −/− −/− NA
12 24.8 REC +/+ −/+ +/+ +/+ +/+ +/+ + + + + + + + + +
13 31.0 LTH, LBC +/+ +/+ +/+ +/+ +/+ +/+ + + + + + + + + + +
14 31.4 LBC, FD −/− −/+ −/+ −/+ −/+ −/− + + + + + + + NA
15
43.5
REC
−/+
−/+
−/+
−/+
+/+
+/+
+



+




+



4 direct
16 30.3 FD NA/ NA −/− −/− −/− −/− −/− NA NA NA NA NA
17 48.9 LBC −/− −/− −/− −/− −/− −/− + + +
18 57.1 NAD −/− −/− −/− −/− −/− −/− + + + + + + + NA
19
57.1
NAD
−/−
−/−
−/−
−/−
−/−
−/−
NA












4 indirect
20 32.7 LBC, FD −/+ NA/+ −/+ −/+ −/− −/− NA + NA + NA NA NA NA NA NA NA NA
21
49.8
Bloat
−/−
−/+
−/−
−/−
−/−
−/−

+
+
+
+
+
+






4 negative controls
22 34.1 FD −/− −/− −/− −/− −/− −/−
23 33.4 FD −/− −/− −/− −/− −/− −/−

*CNS, central nervous system; FD, found dead; LBC, loss of body condition; mpc, months postinoculation; LTH, lethargy; NA, tissue not available for examination; NAD, no abnormalities detected; PrPSc, scrapie prion protein; REC, recumbency.
†Sign before the slash indicated histopathology result (presence [+] or absence [–] of spongiform change); sign after the slash indicates the PrPSc result (presence [+] or absence [–] of PrPSc deposits).
‡Presence (+) or absence (–) of PrPSc deposits as determined by immunohistochemical analysis.
§Presence (+) or absence (–) of PrPSc deposits as determined by immunohistochemical analysis.
¶Survival times for group 4 reindeer are calculated from the date of mixing of the direct controls with group 1 (reindeer challenged with chronic wasting disease from mule deer).
#Intercurrent death.

Main Article

1Deceased.

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