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Volume 22, Number 12—December 2016
CME ACTIVITY - Research

Electrolyte and Metabolic Disturbances in Ebola Patients during a Clinical Trial, Guinea, 2015

Johan van GriensvenComments to Author , Elhadj Ibrahima Bah, Nyankoye Haba, Alexandre Delamou, Bienvenu Salim Camara, Kadio Jean-Jacques Olivier, Hilde De Clerck, Helena Nordenstedt, Malcolm G. Semple, Michel Van Herp, Jozefien Buyze, Maaike De Crop, Steven Van Den Broucke, Lutgarde Lynen, Anja De Weggheleire, and the Ebola-Tx Consortium
Author affiliations: Institute of Tropical Medicine, Antwerp, Belgium (J. van Griensven, J. Buyze, M. De Crop, S. Van Den Broucke, L. Lynen, A. De Weggheleire); Donka National Hospital, Conakry, Guinea (E.I. Bah); National Blood Transfusion Center, Conakry (N. Haba, B.S. Camara, K.J.-J. Olivier); National Center for Training and Research in Rural Health of Maferinyah, Forecariah, Guinea (A. Delamou); Médecins Sans Frontières, Brussels, Belgium (H. De Clerck, H. Nordenstedt, M. Van Herp); University of Liverpool, Liverpool, United Kingdom (M.G. Semple)

Main Article

Table 3

Factors associated with increased risk for death among 78 Ebola patients recruited for the Ebola-Tx trial, Conakry, Guinea, 2015*

Blood test result† POC model
 POC+ model,‡ aOR (95% CI)
Crude OR (95% CI) aOR (95% CI)
K+, per unit increase 1.7 (0.9–3.3) – –
iCa2+, per 0.1-unit increase) 0.70 (0.59–0.84) 0.78 (0.63–0.96) 0.73 (0.57–0.95)
Glucose, per 50-unit increase) 0.87 (0.50–1.52) – –
Creatinine, per 100-unit increase) 2.1 (1.5–3.0) 2.1 (1.3–3.3) 2.3 (1.1–4.6)
TCO2, per 5-unit increase) 0.38 (0.20–0.74) – –
Anion gap, per 5-unit increase) 1.5 (0.6–3.7) – –
Hemoglobin, per 1-unit increase) 1.0 (0.9–1.2) 0.79 (0.63–0.99) 0.67 (0.47–0.93)
Ct value, per 1-unit increase) 0.80 (0.70–0.93) 0.73 (0.56–0.94)
Age, per 10-y increase) 1.8 (1.3–2.6) 2.7 (1.2–6.4)

*aOR, adjusted odds ratio; Ct, cycle threshold; iCa2+, ionized (free) calcium; K+, potassium; OR, odds ratio; POC, point-of-care; TCO2, total dissolved carbon dioxide.
†No evidence of nonlinearity of the continuous variables except for glucose, which was transformed to the power of –2.
‡POC+ model includes 3 POC measurements (blood creatinine, calcium, and hemoglobin) plus the cycle threshold value of the diagnostic Ebola PCR result and the age of the patient.

Main Article

Page created: November 17, 2016
Page updated: November 17, 2016
Page reviewed: November 17, 2016
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