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Volume 23, Number 1—January 2017

Meningitis Associated with Simultaneous Infection by Multiple Dengue Virus Serotypes in Children, Brazil

Paula Eillanny Silva Marinho1, Danilo Bretas de Oliveira1, Talitah Michel Sanchez Candiani, Ana Paula Correia Crispim, Pedro Paulo Martins Alvarenga, Fabrizia Cristina dos Santos Castro, Jonatas Santos Abrahão, Maria Rios, Roney Santos Coimbra, and Maurício Teixeira LimaComments to Author 
Author affiliations: Universidade Federal de Minas Gerais, Minas Gerais, Brazil (P.E.S. Marinho, D.B. de Oliveira, A.P.C. Crispim, J.S. Abrahão, E.G. Kroon); Hospital Infantil João Paulo II, Minas Gerais (T.M.S. Candiani, P.P.M. Alvarenga. F.C.S. Castro); Food and Drug Administration, Silver Spring, Maryland, USA (M. Rios); Fundação Oswaldo Cruz, Minas Gerais (R.S. Coimbra); Universidade Federal dos Vales do Jequitinhonha e Mucuri, Minas Gerais (D.B. de Oliveira)

Main Article


Information and laboratory analyses during hospital admission of pediatric patients suspected of having viral CNS infection, Minas Gerais, Brazil*

Patient no. Age, y/sex Days hospitalized Hemogram†
RT-PCR result Hospital diagnosis DENV IgM
Hct PLT Leuk Protein Glucose Leuk PMN
100 3/F 70 42.1 205 8.4 50 75 30 40 DENV-1 Dengue +
557 9/F 6 38.1 206 17.4 30 70 28 29 DENV-1/2/3 Dengue +
571 9/F 3 43.1 243 9.7 24 63 15 86 DENV-2/3 Dengue/viral meningitis +
572 0.6/M ND 35.2 365 8 11 54 2 4 DENV-3 Viral meningitis
575 0.9/F 5 23.3 522 10.7 97 65 176 1 DENV-2 Viral meningitis
577 6 8 39.1 230 9 35 62 42 10 DENV-2 Dengue +
606 0.4/M 3 35 507 7.1 34 45 5 2 DENV-2 Acute otitis

*CNS, central nervous system; CSF, cerebrospinal fluid; DENV, dengue virus; Hct, hematocrit; leuk, leukocytes; ND, not done; PLT, platelets; PMN,
polymorphonuclear neutrophils; +, positive; –, negative.
†Units: Hct, %; PLT, x 103/mL; leuk, × 103 cells/mm3.
‡These laboratory analyses correspond to the first examination made during the acute phase of CNS infection. Units: protein, g/L; glucose, mmol/L; leuk, × 103 cells/mm3; PMN, %.

Main Article

1These authors contributed equally to this article.

Page created: December 14, 2016
Page updated: December 14, 2016
Page reviewed: December 14, 2016
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