Volume 23, Number 10—October 2017
Dispatch
Macrolide-Resistant Mycoplasma pneumoniae Infection, Japan, 2008–2015
Takaaki Tanaka, Tomohiro Oishi
, Ippei Miyata, Shoko Wakabayashi, Mina Kono, Sahoko Ono, Atsushi Kato, Yoko Fukuda, Aki Saito, Eisuke Kondo, Hideto Teranishi, Yuhei Tanaka, Tokio Wakabayashi, Hiroto Akaike, Satoko Ogita, Naoki Ohno, Takashi Nakano, Kihei Terada, and Kazunobu Ouchi
, Ippei Miyata, Shoko Wakabayashi, Mina Kono, Sahoko Ono, Atsushi Kato, Yoko Fukuda, Aki Saito, Eisuke Kondo, Hideto Teranishi, Yuhei Tanaka, Tokio Wakabayashi, Hiroto Akaike, Satoko Ogita, Naoki Ohno, Takashi Nakano, Kihei Terada, and Kazunobu Ouchi
Table 2
Rates of macrolide-resistant Mycoplasma pneumoniae and point mutations in domain V of 23S rRNA, Japan
| Variable | 2008 | 2009 | 2010 | 2011 | 2012 | 2013 | 2014 | 2015 | Total |
|---|---|---|---|---|---|---|---|---|---|
| Macrolide resistance, % (no. positive/total no. patients) |
55.6 (10/18) |
72.7 (8/11) |
69.0 (80/116) |
65.8 (319/485) |
81.6 (493/604) |
65.8 (25/38) |
59.3 (16/27) |
43.6 (65/149) |
70.2 (1,016/
1,448) |
| Point mutations, no. (%) | |||||||||
| A2063G | 10 (100) | 8 (100) | 80 (100) | 301 (94.4) | 471 (95.5) | 25 (100) | 16 (100) | 62 (95.2) | 97.3 (95.8) |
| A2063C | 0 | 0 | 0 | 3 (0.9) | 0 | 0 | 0 | 0 | 3 (0.3) |
| A2063T | 0 | 0 | 0 | 15 (4.7) | 14 (2.3) | 0 | 0 | 2(3.2) | 31 (3.1) |
| A2064G | 0 | 0 | 0 | 0 | 6 (1.0) | 0 | 0 | 0 | 6 (0.6) |
| C2617G | 0 | 0 | 0 | 0 | 2 (0.3) | 0 | 0 | 0 | 2 (0.2) |
| C2617T | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 (1.6) | 1 (0.1) |
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