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Volume 23, Number 10—October 2017

Dispatch

Hantavirus Pulmonary Syndrome Caused by Maripa Virus in French Guiana, 2008–2016

Séverine MatheusComments to Author , Hatem Kallel, Claire Mayence, Laetitia Bremand, Stéphanie Houcke, Dominique Rousset, Vincent Lacoste, Benoit de Thoisy, Didier Hommel, and Anne Lavergne
Author affiliations: Institut Pasteur de la Guyane, Cayenne, French Guiana (S. Matheus, L. Bremand, D. Rousset, V. Lacoste, B. de Thoisy, A. Lavergne); Centre Hospitalier de Cayenne, Cayenne (H. Kallel, C. Mayence, S. Houcke, D. Hommel)

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Table

Clinical characteristics of 5 male patients infected with Maripa virus, French Guiana, 2008–2016*

Characteristic Reference range Patient
Mean (min–max) SD No. (%) patients
1 2 3 4 5
Year case reported 2008 2009 2010 2013 2016
Age, y 38 56 49 67 71 56.2 (38.0–71.0) 13.4
Location of residence Tonate-Macouria Rémire-Montjoly Tonate-Macouria Tonate-Macouria Iracoubo
Day of hospital admission after symptom onset

7
4
2
4
4
4.2 (2.0–7.0)
1.8

Characteristics at admission to ICU
Heart rate, beats/min 140 150 140 168 170 154 (140–170) 15
Shock Yes Yes Yes Yes Yes 5 (100)
Acute lung injury Yes Yes Yes Yes Yes 5 (100)
Acute kidney injury Yes Yes Yes Yes Yes 5 (100)
Urea nitrogen, mmol/L 1.7–8.3 9.3 10.0 10.7 13.7 6.4 10.0 (6.4–13.7) 2.6
Creatinine, µmol/L 62–106 192 174 196 196 126 176.8 (126.0–196.0) 29.8
Serum protein, g/L 60–80 44.8 69.0 30.1 57.0 55.0 51.2 (30.1–69.0) 14.6
Lactate, mmol/L 0.63–2.44 2.2 8.0 5.3 3.1 5.0 4.7 (2.2–8.0) 2.2
Leukocytes, ×109 cells/L 4–10 22.5 21.1 19.5 9.6 9.7 16.5 (9.6–22.5) 6.3
Platelet count, ×109/L 150–400 50 149 67 125 79 94.0 (50.0–149.0) 41.5
Hematocrit, % 38–51 50.5 66.6 55.9 52.6 41.7 53.5 (41.7–66.6) 9.0
AST, IU/L <37 17 49 10 18 17 22.2 (10.0–49.0) 15.3
ALT, IU/L <40 31 47 24 58 29 37.8 (24.0–58.0) 14.2
Bilirubin, µmol/L <17 3.4 8.2 6.0 6.0 4.6 5.6 (3.4–8.2) 1.8
CPK, U/L 38–174 215 119 149 181 262 185.2 (119.0–262.0) 55.9
Troponin, µg/L <0.1 ND ND 0.20 0.06 0.25 0.17 (0.06–0.25) 0.10
CRP, mg/L
<10
192.0
166.0
93.3
92.4
154
139.5 (92.4–192.0)
44.8

Death No Yes Yes Yes Yes 4 (80)
Time of death after admission, h NA 2 6 16 14 9.5 (2.0–16.0) 6.6

*ALT, alanine aminotransferase; AST, aspartate aminotransferase; CPK, creatine phosphokinase; CRP, C-reactive protein; ICU, intensive care unit; max, maximum; min, minimum; NA, not applicable; ND, not determined.

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