Avian Influenza A(H7N2) Virus in Human Exposed to Sick Cats, New York, USA, 2016
Atanaska Marinova-Petkova, Jen Laplante, Yunho Jang, Brian Lynch, Natosha Zanders, Marisela Rodriguez, Joyce Jones, Sharmi Thor, Erin Hodges, Juan A. De La Cruz, Jessica A. Belser, Hua Yang, Paul Carney, Bo Shu, LaShondra Berman, Thomas Stark, John Barnes, Fiona Havers, Patrick Yang, Susan C. Trock, Alicia Fry, Larisa Gubareva, Joseph S. Bresee, James Stevens, Demetre Daskalakis, Dakai Liu, Christopher Lee, Mia Kim Torchetti, Sandra Newbury, Francine Cigel, Kathy L. Toohey-Kurth, Kirsten St. George, David Wentworth, Stephen Lindstrom, and C. Todd Davis
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A. Marinova-Petkova, Y. Jang, B. Lynch, N. Zanders, M. Rodriguez, J. Jones, S. Thor, E. Hodges, J.A. De La Cruz, J. Belser, H. Yang, P. Carney, B. Shu, L. Berman, T. Stark, J. Barnes, F. Havers, P. Yang, S.C. Trock, A. Fry, L. Gubareva, J.S. Bresee, J. Stevens, D.E. Wentworth, S. Lindstrom, C.T. Davis); New York State Department of Health, Albany, New York, USA (J. Laplante, K. St. George); New York City Department of Health and Mental Hygiene, Long Island City, New York, USA (D. Daskalakis, D. Liu, C.T. Lee); US Department of Agriculture, Ames, Iowa, USA (M.K. Torchetti); University of Wisconsin, Madison, Wisconsin, USA (S. Newbury, F. Cigel, K. Toohey-Kurth)
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Figure 2
Figure 2. Receptor binding specificity of A/New York/108/2016 (H7N2) influenza virus isolated from a human who experienced influenza-like illness after exposure to sick domestic cats at an animal shelter in New York, NY, USA, 2016. Figure shows A/New York/108/2016 hemagglutinin (HA) monomer structure. HA1 is shown in gray, HA2 in light purple, amino acid changes in comparison with reference virus A/turkey/Virginia/4529/2002 (H7N2) in red. On the cartoon view (left), all amino acid changes in the HA protein are labeled. The location of the receptor binding site (blue circle) includes the 120-loop and the 180-helix. The 220-loop is missing due to deletion of amino acids 212–219 in the mature HA protein (H7 numbering). On the surface model (right), only amino acid substitutions adjacent to the antigenic sites and receptor binding site are labeled. Antigenic site B is yellow, antigenic site C green.
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