Skip directly to site content Skip directly to page options Skip directly to A-Z link Skip directly to A-Z link Skip directly to A-Z link
Volume 23, Number 3—March 2017
CME ACTIVITY - Synopsis

Three Cases of Neurologic Syndrome Caused by Donor-Derived Microsporidiosis

Rachel SmithComments to Author , Atis Muehlenbachs, Joanna Schaenmann, Sanjiv Baxi, Sophia Koo, Dianna Blau, Peter Chin-Hong, Anna R. Thorner, Matthew J. Kuehnert, Kristina Wheeler, Alexis Liakos, Jonathan W. Jackson, Theresa Benedict, Alexandre J. da Silva, Jana M. Ritter, Dominique Rollin, Maureen Metcalfe, Cynthia S. Goldsmith, Govinda S. Visvesvara, Sridhar V. Basavaraju, and Sherif Zaki
Author affiliations: Centers for Disease Control and Prevention, Atlanta, Georgia, USA (R.M. Smith, A. Muehlenbachs, D. Blau, M.J. Kuehnert, J.W. Jackson, T. Benedict, A.J. da Silva, J.M. Ritter, D. Rollin, M. Metcalfe, C.S. Goldsmith, G.S. Visvesvara, S.V. Basavaraju, S. Zaki); University of California, Los Angeles, California, USA (J. Schaenmann); University of California, San Francisco, California, USA (S. Baxi, P. Chin-Hong); Brigham and Women’s Hospital, Boston, Massachusetts, USA (S. Koo, A.R. Thorner, A. Liakos); Harvard Medical School, Boston (S. Koo, A.R. Thorner, A. Liakos); OneLegacy, Los Angeles (K. Wheeler)

Main Article

Table 2

Transplant recipient testing for microsporidiosis, by specimen and test type*

Patient Specimen IHC TEM PCR† Culture
Right kidney recipient
 Renal allograft + + + Not performed
CNS tissue‡
 +
 +
 Not performed
 Not performed
Left kidney/heart recipient
 Renal allograft – Not performed + Not performed
Cardiac allograft Indeterminate - – Not performed
Bone marrow – Not performed – Not performed
Urine
 Not performed
 Not performed
 +
 Not performed
Liver recipient Urine + + + +

*CNS, central nervous system; IHC, immunohistochemistry; TEM, transmission electron microscopy; +, positive; –, negative.
†All PCR positive tests confirmed Encephalitozoon cuniculi
‡CNS tissue included cortex and brainstem.

Main Article

Page created: February 15, 2017
Page updated: February 15, 2017
Page reviewed: February 15, 2017
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. Use of trade names is for identification only and does not imply endorsement by any of the groups named above.
file_external