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Volume 23, Number 5—May 2017

Research

Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

Matthew H. CollinsComments to Author , Eileen McGowan, Ramesh Jadi, Ellen Young, Cesar A. Lopez, Ralph S. Baric, Helen M. Lazear, and Aravinda M. de SilvaComments to Author 
Author affiliations: University of North Carolina, Chapel Hill, North Carolina, USA

Main Article

Figure 3

Use of depletion of human serum with DENV antigen to distinguish Zika virus–specific from cross-reactive flavivirus antibodies. A) Depletion efficiency was determined by direct ELISA. Plates were coated with depleting antigens (DENV-1 and DENV-2) and binding of control and depleted serum was measured. B–E) Binding of depleted serum to Zika virus H/PF/2013 was measured by capture ELISA. BSA, bovine serum albumin; DENV, dengue virus; OD, optical density.

Figure 3. Use of depletion of human serum with DENV antigen to distinguish Zika virus–specific from cross-reactive flavivirus antibodies. A) Depletion efficiency was determined by direct ELISA. Plates were coated with depleting antigens (DENV-1 and DENV-2) and binding of control and depleted serum was measured. B–E) Binding of depleted serum to Zika virus H/PF/2013 was measured by capture ELISA. BSA, bovine serum albumin; DENV, dengue virus; OD, optical density.

Main Article

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