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Volume 23, Number 5—May 2017

Research

Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

Matthew H. CollinsComments to Author , Eileen McGowan, Ramesh Jadi, Ellen Young, Cesar A. Lopez, Ralph S. Baric, Helen M. Lazear, and Aravinda M. de SilvaComments to Author 
Author affiliations: University of North Carolina, Chapel Hill, North Carolina, USA

Main Article

Table 1

DENV and Zika virus neutralization profiles for persons with travel history to Zika virus–endemic areas*

Serostatus, serum sample ID
Place of Infection
IC50
DENV-1
DENV-2
DENV-3
DENV-4
Zika virus
Primary DENV-1
147 Latin America 3,552 287 557 75 <20
153 Latin America 757 <20 <20 <20 <20
05/262 Asia 274 <20 <20 <20 <20
06/125 Asia 3,823 222 125 80 <20
99/1230
Asia
1,219
63
30
24
<20
Primary DENV-2
001 Asia 49 2,188 48 89 <20
08/90 Asia <20 2,966 <20 <20 <20
08/91 Asia <20 838 <20 <20 <20
09/165 Asia <20 2,093 <20 <20 <20
09/251
Asia
<20
417
<20
<20
<20
Primary DENV-3
116 Asia 200 979 5,342 290 <20
118 Latin America 173 374 3,041 56 <20
125 Latin America 99 97 1,648 35 <20
133 Latin America 89 171 3,348 83 <20
06/297
Asia
27
<20
573
<20
<20
Primary DENV-4
112 Latin America 908 1367 591 18,408 <20
06/105 Asia <20 <20 <20 941 <20
06/302 Asia <20 <20 <20 4,130 <20
09/159
Asia
115
226
478
5,694
<20
Primary Zika virus
168 Latin America 36ǂ <20 78‡ <20 1,382
172
Latin America
<20
<20
<20
<20
8,468
Secondary DENV
000 Asia 3,306 2,087 1,162 782 <20
003 Asia 556 178 299 <20 146
115 Asia 100 355 830 245 <20
141 Latin America 1,902 1,953 4,530 664 <20
144 Asia 155 191 5,782 1,612 699
145 Asia 601 1,262 240 60 <20
146 Asia 403 1,052 1,480 451 28
155 Asia 215 299 71 27 <20
160 Latin America 947 3,564 131 1,600 <20
06/123 Asia 1,776 827 82 157 <20
06/124 Asia 1,454 1,208 1,673 1,011 <20
09/157 Asia 282 1,104 73 134 <20
09/250
Asia
375
1475
151
94
<20
Secondary Zika virus
165 Latin America 60‡ 79‡ 70‡ 508 1655
166 Latin America 929 393 4344 240 1814

*DENV, dengue virus; IC50, 50% inhibitory concentration; ID, identification.
†All neutralization testing performed on Vero cells with the exception of DT003, which was limiting and historic values performed on a U937 Flow-based assay are shown for DENV-1–4. Zika virus IC50 values for DT003 are from Vero assays.
‡Curves that did not pass quality metrics are marked. Such curves might signify very low titer IC50 values or variable background at the lower limit of detection in serum with no specific neutralization activity.

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